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How to get fromBuffalo to San Diegoby plane, train (Amtrak), bus (Greyhound, Amtrak), car, or shuttle

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There are 5 ways to get from Buffalo to San Diego by plane, train (Amtrak), bus (Greyhound, Amtrak), car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Buffalo Niagara International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to San Diego International Airport (SAN)plane plane BUF - SAN
    7h 55m
    $272–1,128

  2. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain train
    3. Take the train from Fullerton Amtrak Station to San Diegotrain train
    2d 10h
    $902–2,055

  3. Bus

    1. Take the bus from Buffalo to Columbusbus bus
    2. Take the bus from Columbus to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Los Angeles Union Stationbus bus
    4. Take the bus from Los Angeles to San Diegobus bus
    2d 12h
    $440–875

  4. Drive 2,534.6 mi

    1. Drive from Buffalo to San Diegocar car 2,534.6 mi
    41h 42m
    $463–669

  5. Shuttle to Toronto Pearson International Airport, fly

    1. Take a shuttle bus from Buffalo Airport to Pearson International Airport Terminal 1shuttle bus
    2. Fly from Toronto Pearson International Airport (YYZ) to San Diego International Airport (SAN)plane plane YYZ - SAN
    10h 21m
    $332–1,222

Buffalo to San Diego by train (Amtrak)

Calendar7Weekly Trains
Duration2d 10hAverage Duration
Ticket$902Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to San Diego.ExpandLaunch map view
  • Distance: 2,202.9 mi
  • Duration: 7h 55m

What companies run services between Buffalo, NY, USA and San Diego, CA, USA?

Southwest Airlines, Delta, and two other airlines fly from Buffalo Niagara International Airport (BUF) to San Diego International Airport (SAN) every 3 hours. Alternatively, you can take a train from Buffalo to San Diego via Buffalo Depew Station, Chicago Union Station, and Fullerton Amtrak Station in around 2d 10h.

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