Rome2Rio

How to get fromBuffalo to San Diegoby plane, train (Amtrak), bus (Greyhound, Amtrak), car, or bus

Find Transport to San Diego

See all options

There are 6 ways to get from Buffalo to San Diego by plane, train (Amtrak), bus (Greyhound, Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Buffalo Niagara International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to San Diego International Airport (SAN)plane plane BUF - SAN
    8h 26m
    $162–702

  2. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain train
    3. Take the train from Fullerton Amtrak Station to San Diegotrain train
    2d 10h
    $1,547–2,573

  3. Bus

    1. Take the bus from Buffalo to Columbusbus bus
    2. Take the bus from Columbus to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Los Angeles Union Stationbus bus
    4. Take the bus from Los Angeles to San Diegobus bus
    2d 14h

  4. Drive  2,534.6 mi

    1. Drive from Buffalo to San Diegocar car 2,534.6 mi
    41h 42m
    $463–669

  5. Bus to Rochester, fly

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to San Diego International Airport (SAN)plane plane ROC - SAN
    9h 44m
    $250–943

  6. Bus to Toronto Pearson International Airport, fly

    1. Take the bus from Buffalo to Mississaugabus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to San Diego International Airport (SAN)plane plane YYZ - SAN
    10h 19m
    $437–1,009

Buffalo to San Diego by train (Amtrak)

Calendar7Weekly Trains
Duration2d 10hAverage Duration
Ticket$1,547Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Buffalo to San Diego.ExpandLaunch map view
  • Distance: 2,204.7 mi
  • Duration: 8h 26m

What companies run services between Buffalo, NY, USA and San Diego, CA, USA?

Southwest Airlines, Delta, and United Airlines fly from Buffalo Niagara International Airport (BUF) to San Diego International Airport (SAN) every 4 hours. Alternatively, you can take a train from Buffalo to San Diego via Buffalo Depew Station, Chicago Union Station, and Fullerton Amtrak Station in around 2d 10h.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There