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How to get fromBuffalo to Sanfordby plane, taxi, bus (Greyhound), train (Amtrak), car, train, or bus (Flixbus, Greyhound)

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There are 7 ways to get from Buffalo to Sanford by plane, taxi, bus (Greyhound), train (Amtrak), car, train, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Portland, taxi

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Portland (PWM)plane plane BUF - PWM
    2. Take the taxi from Portland-Airport-PWM to Sanfordtaxi taxi
    5h 27m
    $206–708

  2. Drive 475.4 mi

    cheapest
    1. Drive from Buffalo to Sanfordcar car 475.4 mi
    9h 39m
    $87–126

  3. Bus (Greyhound)

    1. Take the bus from Buffalo to Bostonbus bus Greyhound US0171
    2. Take the bus from Boston to Wells Transportation Centerbus bus Greyhound US0265s
    13h 6m
    $122–212

  4. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Bostontrain train Lake Shore Limited
    2. Take the train from Boston to Wellstrain train Downeaster
    15h 57m
    $221–575

  5. Fly to Manchester Airport, drive

    1. Fly from Buffalo Niagara International Airport (BUF) to Manchester Airport (MHT)plane plane BUF - MHT
    2. Drive from Manchester-Airport-MHT to Sanfordcar car
    6h 39m
    $106–543

  6. Fly to Boston Logan Airport, train

    1. Fly from Buffalo Niagara International Airport (BUF) to Boston Logan Airport (BOS)plane plane BUF - BOS
    2. Take the train from Woburn Amtrak Station to Wellstrain train
    6h 18m
    $147–562

  7. Bus via Ithaca

    1. Take the bus from Buffalo to Ithacabus bus
    2. Take the bus from Ithaca to Bostonbus bus
    3. Take the bus from Boston to Wells Transportation Centerbus bus
    15h 41m
    $137–221

Buffalo Niagara International Airport (BUF) to Portland (PWM) flights

Calendar106Weekly Planes
Duration4h 43mAverage Duration
Ticket$101Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to Sanford.ExpandLaunch map view
  • Distance: 468.9 mi
  • Duration: 5h 27m

What companies run services between Buffalo, NY, USA and Sanford, ME, USA?

You can take a bus from Buffalo to Sanford via Boston and Wells Transportation Center in around 13h 6m. Alternatively, you can take a train from Buffalo to Sanford via Buffalo Depew Station, Boston, Back Bay, North Station, Boston, and Wells in around 15h 57m.

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