There are 6 ways to get from Buffalo to Santa Clara by plane, bus (Greyhound), train (Amtrak), car, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Norman Y. Mineta San José International Airport
best- Fly from Buffalo Niagara International Airport (BUF) to Norman Y. Mineta San José International Airport (SJC)plane BUF - SJC
8h 20m$269–1,131Fly to San Francisco International Airport, Caltrain
cheapest- Fly from Buffalo Niagara International Airport (BUF) to San Francisco International Airport (SFO)plane BUF - SFO
- Take the train from Millbrae Caltrain Southbound to Santa Clara Caltrain Southboundtrain
9h 26m$141–598Bus
- Take the bus from Buffalo, NY to Columbus - Mound Stbus
- Take the bus from Columbus to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Los Angeles Union Stationbus
- Take the bus from Los Angeles, CA - Chinatown Station to San Jose, CA - Huong Lan Sandwichbus
2d 18h$424–817Train (Amtrak)
- Take the train from Buffalo Depew Station to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Emeryvilletrain
- Take the train from Emeryville to Santa Clara Amtraktrain
2d 19h$926–2,120Drive 2,670.6 mi
- Drive from Buffalo to Santa Claracar 2,670.6 mi
42h 9m$488–704Fly to Oakland International Airport, train
- Fly from Buffalo Niagara International Airport (BUF) to Oakland International Airport (OAK)plane BUF - OAK
- Take the train from Oakland Coliseum/Airport Amtrak to Santa Clara Amtraktrain
9h 59m$289–1,156
Buffalo to Santa Clara by bus and tram
Questions & Answers
The cheapest way to get from Buffalo to Santa Clara is to fly and Caltrain which costs $140 - $600 and takes 9h 26m.
The fastest way to get from Buffalo to Santa Clara is to fly which takes 8h 20m and costs $260 - $1,200.
No, there is no direct bus from Buffalo to Santa Clara. However, there are services departing from Buffalo, NY and arriving at El Camino & Lincoln via Columbus, St Louis Bus Station, Los Angeles, CA - Chinatown Station and King & Tully. The journey, including transfers, takes approximately 2 days 18h.
No, there is no direct train from Buffalo to Santa Clara. However, there are services departing from Buffalo and arriving at Santa Clara Amtrak via Buffalo Depew Station, Chicago Union Station and Emeryville. The journey, including transfers, takes approximately 2 days 19h.
The distance between Buffalo and Santa Clara is 2316 miles. The road distance is 2686.2 miles.
The best way to get from Buffalo to Santa Clara without a car is to bus which takes 2 days 18h and costs $420 - $850.
It takes approximately 8h 20m to get from Buffalo to Santa Clara, including transfers.
Buffalo to Santa Clara bus services, operated by Barons Bus, depart from Buffalo, NY station.
Buffalo to Santa Clara train services, operated by Amtrak, depart from Buffalo Depew Station.
The best way to get from Buffalo to Santa Clara is to fly which takes 8h 20m and costs $260 - $1,200. Alternatively, you can bus, which costs $420 - $850 and takes 2 days 18h, you could also train, which costs $900 - $2,200 and takes 2 days 19h.
What companies run services between Buffalo, NY, USA and Santa Clara, CA, USA?
Southwest Airlines and United Airlines fly from Buffalo Niagara International Airport (BUF) to Norman Y. Mineta San José International Airport (SJC) every 4 hours. Alternatively, you can take a bus from Buffalo, NY to El Camino & Lincoln via Columbus, St Louis Bus Station, Los Angeles Union Station, Union Station - Metro A-Line, Chinatown Station, Los Angeles, CA - Chinatown Station, San Jose, CA - Huong Lan Sandwich, and King & Tully in around 2d 18h.
- Website
- southwest.com
Flights from Buffalo Niagara International Airport to Norman Y. Mineta San José International Airport via Denver
- Ave. Duration
- 7h 22m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $260–1,100
Flights from Buffalo Niagara International Airport to Norman Y. Mineta San José International Airport via Las Vegas
- Ave. Duration
- 7h 26m
- When
- Saturday, Monday, Thursday, Friday, and Sunday
- Estimated price
- $260–1,100
Flights from Buffalo Niagara International Airport to Norman Y. Mineta San José International Airport via Chicago Midway
- Ave. Duration
- 7h 15m
- When
- Every day
- Estimated price
- $260–1,100
Flights from Buffalo Niagara International Airport to San Francisco International Airport via Denver
- Ave. Duration
- 7h 11m
- When
- Saturday, Monday, Thursday, and Friday
- Estimated price
- $180–700
Flights from Buffalo Niagara International Airport to San Francisco International Airport via Chicago Midway
- Ave. Duration
- 7h 28m
- When
- Monday to Wednesday
- Estimated price
- $180–700
Flights from Buffalo Niagara International Airport to San Francisco International Airport via Las Vegas
- Ave. Duration
- 8h 33m
- When
- Sunday, Monday, Thursday, Friday, and Saturday
- Estimated price
- $180–750
Flights from Buffalo Niagara International Airport to Oakland International Airport via Denver
- Ave. Duration
- 6h 55m
- When
- Monday, Thursday, Friday, and Saturday
- Estimated price
- $270–1,100
Flights from Buffalo Niagara International Airport to Oakland International Airport via Chicago Midway
- Ave. Duration
- 6h 57m
- When
- Monday to Wednesday
- Estimated price
- $270–1,100
Flights from Buffalo Niagara International Airport to Oakland International Airport via Las Vegas
- Ave. Duration
- 7h 48m
- When
- Sunday, Monday, Thursday, Friday, and Saturday
- Estimated price
- $280–1,100
Flights from Buffalo Niagara International Airport to Oakland International Airport via Dallas
- Ave. Duration
- 11h 35m
- When
- Sunday
- Estimated price
- $310–1,200
- Website
- united.com
Flights from Buffalo Niagara International Airport to Norman Y. Mineta San José International Airport via Denver
- Ave. Duration
- 7h 13m
- When
- Every day
- Estimated price
- $260–1,100
Flights from Buffalo Niagara International Airport to Norman Y. Mineta San José International Airport via Chicago O'Hare
- Ave. Duration
- 7h 51m
- When
- Every day
- Estimated price
- $260–1,100
Flights from Buffalo Niagara International Airport to San Francisco International Airport via Chicago O'Hare
- Ave. Duration
- 8h 17m
- When
- Every day
- Estimated price
- $180–700
Flights from Buffalo Niagara International Airport to San Francisco International Airport via Denver
- Ave. Duration
- 9h 21m
- When
- Every day
- Estimated price
- $180–700
- Website
- delta.com
Flights from Buffalo Niagara International Airport to San Francisco International Airport via Detroit
- Ave. Duration
- 8h 23m
- When
- Every day
- Estimated price
- $180–700
Flights from Buffalo Niagara International Airport to San Francisco International Airport via Minneapolis
- Ave. Duration
- 7h 14m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $180–700
- Website
- aa.com
Flights from Buffalo Niagara International Airport to San Francisco International Airport via Chicago O'Hare
- Ave. Duration
- 9h 14m
- When
- Every day
- Estimated price
- $180–700
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Buffalo Depew Station to Chicago Union Station
- Ave. Duration
- 10h 33m
- Frequency
- Twice daily
- Estimated price
- $160–350
- Website
- Amtrak
Train from Chicago Union Station to Emeryville
- Ave. Duration
- 2d 4h
- Frequency
- Once daily
- Estimated price
- $750–1,600
- Website
- Amtrak
Train from Emeryville to Santa Clara Amtrak
- Ave. Duration
- 1h 12m
- Frequency
- Every 4 hours
- Estimated price
- $14–35
- Website
- Amtrak
Train from Oakland Coliseum/Airport Amtrak to Santa Clara Amtrak
- Ave. Duration
- 51 min
- Frequency
- Every 4 hours
- Estimated price
- $11–25
- Website
- Amtrak
- Phone
- +1 800-660-4287
- Website
- Cal Train
Train from Millbrae Caltrain Southbound to Santa Clara Caltrain Southbound
- Ave. Duration
- 50 min
- Frequency
- Every 30 minutes
- Estimated price
- $7–9
- Website
- Cal Train
- Schedules at
- Cal Train
- One-way Adult
- $7–9
- Phone
- +1 888-378-3823
- [email protected]
- Website
- Barons Bus
Bus from Buffalo, NY to Columbus - Mound St
- Ave. Duration
- 7h 5m
- Frequency
- Once daily
- Estimated price
- $35–80
- Website
- Barons Bus
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Columbus to St Louis Bus Station
- Ave. Duration
- 9h 5m
- Frequency
- Every 4 hours
- Estimated price
- $60–120
- Website
- Greyhound
Bus from St Louis Bus Station to Los Angeles Union Station
- Ave. Duration
- 40h 30m
- Frequency
- Twice daily
- Estimated price
- $280–550
- Website
- Greyhound
- Phone
- +1 714-839-3500
- [email protected]
- Website
- Hoang Bus
Bus from Los Angeles, CA - Chinatown Station to San Jose, CA - Huong Lan Sandwich
- Ave. Duration
- 5h 45m
- Frequency
- Once daily
- Estimated price
- $45–60
- Book at
- GoToBus - Hoang Express
- Website
- Hoang Bus
- Adult One-way
- $45–60
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More Questions & Answers
Buffalo to Santa Clara bus services, operated by Barons Bus, arrive at Columbus - Mound St station.
Santa Clara is 3h behind Buffalo. It is currently 8:21 PM in Buffalo and 5:21 PM in Santa Clara.
Buffalo to Santa Clara train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Buffalo to Santa Clara is 2686 miles. It takes approximately 42h 9m to drive from Buffalo to Santa Clara.
Book your Buffalo to Santa Clara train tickets online with Omio.
There are 509+ hotels available in Santa Clara.

















