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How to get fromBuffalo to Spartanburgby plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus (Flixbus, Greyhound)

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There are 6 ways to get from Buffalo to Spartanburg by plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Greenville–Spartanburg International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Greenville–Spartanburg International Airport (GSP)plane plane BUF - GSP
    5h 38m
    $167–722

  2. Bus

    cheapest
    1. Take the bus from Buffalo, NY to Robert K Pfaff Transit Center - Akronbus bus
    2. Take the bus from Robert K Pfaff Transit Center - Akron to Charleston, WVbus bus
    3. Take the bus from Charleston, WV to Charlotte Bus Stationbus bus
    4. Take the bus from Charlotte Bus Station to Spartanburgbus bus
    18h 10m
    $106–229

  3. Train (Amtrak)

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Spartanburg Stationtrain train Crescent
    23h 38m
    $286–643

  4. Drive  709.2 mi

    1. Drive from Buffalo to Spartanburgcar car 709.2 mi
    12h 36m
    $130–187

  5. Fly to Charlotte Douglas International Airport, train

    1. Fly from Buffalo Niagara International Airport (BUF) to Charlotte Douglas International Airport (CLT)plane plane BUF - CLT
    2. Take the train from Charlotte Amtrak Station to Spartanburg Stationtrain train
    7h 6m
    $121–653

  6. Bus via Newark

    1. Take the bus from Buffalo to Newark Penn Stationbus bus FlixBus N2686 / ...
    2. Take the bus from Newark Penn Station to Spartanburgbus bus Greyhound US0670
    26h 45m
    $184–295

Buffalo to Spartanburg by train (Amtrak)

Calendar7Weekly Trains
Duration23h 38mAverage Duration
Ticket$286Cheapest Price
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Questions & Answers

Map of how to get from Buffalo to Spartanburg.ExpandLaunch map view
  • Distance: 617.8 mi
  • Duration: 5h 38m

What companies run services between Buffalo, NY, USA and Spartanburg, SC, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Buffalo Niagara International Airport (BUF) to Greenville–Spartanburg International Airport (GSP) hourly. Alternatively, you can take a bus from Buffalo, NY to Spartanburg via Robert K Pfaff Transit Center - Akron, Charleston, WV, Charlotte Bus Station, and Spartanburg in around 18h 10m.

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