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How to get fromBuffalo to Winston-Salemby plane, bus (Greyhound), train (Amtrak), car, bus, or bus (Flixbus, Greyhound)

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There are 8 ways to get from Buffalo to Winston-Salem by plane, bus (Greyhound), train (Amtrak), car, bus, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Piedmont Triad International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Piedmont Triad International Airport (GSO)plane plane BUF - GSO
    6h 23m
    $141–775

  2. Bus

    cheapest
    1. Take the bus from Buffalo, NY to Robert K Pfaff Transit Center - Akronbus bus
    2. Take the bus from Robert K Pfaff Transit Center - Akron to Charleston, WVbus bus
    3. Take the bus from Charleston Bus Station to Winston Salem(Trans Center)bus bus
    15h 25m
    $78–186

  3. Train (Amtrak)

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to High Pointtrain train Crescent / ...
    21h 39m
    $243–554

  4. Drive  601.3 mi

    1. Drive from Buffalo to Winston-Salemcar car 601.3 mi
    10h 27m
    $110–159

  5. Fly to Charlotte Douglas International Airport, bus

    1. Fly from Buffalo Niagara International Airport (BUF) to Charlotte Douglas International Airport (CLT)plane plane BUF - CLT
    2. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    6h 39m
    $108–598

  6. Fly to Raleigh-Durham International Airport, bus

    1. Fly from Buffalo Niagara International Airport (BUF) to Raleigh-Durham International Airport (RDU)plane plane BUF - RDU
    2. Take the bus from Durham to Winston Salem(Trans Center)bus bus
    7h 31m
    $140–448

  7. Bus via Charleston

    1. Take the bus from Buffalo to Akronbus bus
    2. Take the bus from Akron to Charlestonbus bus
    3. Take the bus from Charleston Bus Station to Winston Salem(Trans Center)bus bus
    15h 25m
    $78–186

  8. Bus #2

    1. Take the bus from Buffalo to Columbusbus bus FlixBus 2526
    2. Take the bus from Columbus to Winston Salem(Trans Center)bus bus Greyhound US0140
    17h 2m
    $117–188

Buffalo to Winston-Salem by bus

Calendar7Weekly Buses
Duration15h 25mAverage Duration
Ticket$78Cheapest Price
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Comparing Your Travel Options

Map of how to get from Buffalo to Winston-Salem.ExpandLaunch map view
  • Distance: 511.6 mi
  • Duration: 6h 23m

What companies run services between Buffalo, NY, USA and Winston-Salem, NC, USA?

United Airlines, Delta, and American Airlines fly from Buffalo Niagara International Airport (BUF) to Piedmont Triad International Airport (GSO) hourly. Alternatively, you can take a bus from Buffalo, NY to Winston Salem(Trans Center) via Robert K Pfaff Transit Center - Akron and Charleston Bus Station in around 15h 25m.

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