Rome2Rio

How to get fromBuffalo to Winston-Salemby plane, bus (Greyhound), train, bus, car, or bus (Flixbus)

Find Transport to Winston-Salem

See all options

There are 7 ways to get from Buffalo to Winston-Salem by plane, bus (Greyhound), train, bus, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Buffalo Niagara International Airport to Piedmont Triad International Airport

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to Piedmont Triad International Airport (GSO)plane plane BUF - GSO
    6h 4m
    $90–431

  2. Bus

    cheapest
    1. Take the bus from Buffalo to Akronbus bus
    2. Take the bus from Akron to Charlestonbus bus
    3. Take the bus from Charleston Bus Station to Winston Salem(Trans Center)bus bus
    15h 25m
    $83–191

  3. Train, bus

    1. Take the train from Buffalo to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Greensborotrain train
    3. Take the bus from Greensboro Bus Stop to Winston Salem(Trans Center)bus bus
    21h 17m
    $516–807

  4. Drive  601.3 mi

    1. Drive from Buffalo to Winston-Salemcar car 601.3 mi
    10h 27m
    $103–149

  5. Fly Buffalo Niagara International Airport to Charlotte Douglas International Airport, bus

    1. Fly from Buffalo Niagara International Airport (BUF) to Charlotte Douglas International Airport (CLT)plane plane BUF - CLT
    2. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    6h 27m
    $124–705

  6. Bus to Rochester, fly to Charlotte Douglas International Airport, bus

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Charlotte Douglas International Airport (CLT)plane plane ROC - CLT
    3. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    7h 57m
    $198–970

  7. Bus via New York

    1. Take the bus from Buffalo to New York Midtownbus bus FlixBus 2686 / ...
    2. Take the bus from New York, NY to Winston-Salem, NCbus bus Nyc
    19h 52m
    $150–212

Buffalo to Winston-Salem by bus

Calendar7Weekly Buses
Duration15h 25mAverage Duration
Ticket$83Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Buffalo to Winston-Salem.ExpandLaunch map view
  • Distance: 509.8 mi
  • Duration: 6h 4m

What companies run services between Buffalo, NY, USA and Winston-Salem, NC, USA?

United Airlines, American Airlines, and Delta fly from Buffalo Niagara International Airport (BUF) to Piedmont Triad International Airport (GSO) hourly. Alternatively, you can take a bus from Buffalo to Winston Salem(Trans Center) via Akron, Charleston, and Charleston Bus Station in around 15h 25m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There