There are 7 ways to get from Cali to Antioquia by plane, bus, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Medellin Jose Marie Cordova
best- Fly from Cali (CLO) to Medellin Jose Marie Cordova (MDE)plane CLO - MDE
3h 10m$72–224Drive 422.4 km
cheapest- Drive from Cali to Medellíncar 422.4 km
7h 13m$22–32Bus
- Take the bus from Terminal de Transporte Cali to Terminal del Surbus
8h 24m$30–40Fly to Enrique Olaya Herrera Airport
- Fly from Cali (CLO) to Enrique Olaya Herrera Airport (EOH)plane CLO - EOH
3h 14m$553–1,205Bus via Buga
- Take the bus from Terminal de Transporte Cali to Terminal Guadalajara de Bugabus
- Take the bus from Terminal Guadalajara de Buga to Terminal del Nortebus
9h 7m$33–46Bus via Terminal de Transporte Cali
- Take the bus from Terminal de Transporte Cali to Terminal del Surbus
9h 9m$33–46Bus via Terminal de Transporte Cali #2
- Take the bus from Terminal de Transporte Cali to Terminal del Surbus
10h 39m$26–40
Cali (CLO) to Medellin Jose Marie Cordova (MDE) flights
Comparing Your Travel Options
The cheapest way to get from Cali to Antioquia is to bus via Terminal de Transporte Cali which costs $26 - $40 and takes 10h 39m.
The fastest way to get from Cali to Antioquia is to fly which takes 3h 10m and costs $70 - $230.
No, there is no direct bus from Cali to Antioquia. However, there are services departing from Terminal de Transporte Cali and arriving at Exposiciones via Terminal del Sur. The journey, including transfers, takes approximately 8h 24m.
The distance between Cali and Antioquia is 354 km. The road distance is 422.4 km.
The best way to get from Cali to Antioquia without a car is to bus which takes 8h 24m and costs $29 - $45.
It takes approximately 3h 10m to get from Cali to Antioquia, including transfers.
Cali to Antioquia bus services, operated by Expreso Trejos, depart from Terminal de Transporte Cali station.
The best way to get from Cali to Antioquia is to fly which takes 3h 10m and costs $70 - $230. Alternatively, you can bus, which costs $29 - $45 and takes 8h 24m.
Cali to Antioquia bus services, operated by Expreso Trejos, arrive at Terminal del Sur station.
Yes, the driving distance between Cali to Antioquia is 422 km. It takes approximately 7h 13m to drive from Cali to Antioquia.
What companies run services between Cali, Colombia and Antioquia, Colombia?
JetSMART, Avianca - Aerovías del Continente Americano S.A., and LATAM Chile fly from Cali (CLO) to Medellin Jose Marie Cordova (MDE) every 3 hours. Alternatively, Expreso Trejos operates a bus from Terminal de Transporte Cali to Terminal del Sur 4 times a day. Tickets cost $32 and the journey takes 7h 45m. Bolivariano also services this route every 3 hours.
- Website
- jetsmart.com
Flights from Cali to Medellin Jose Marie Cordova
- Ave. Duration
- 55 min
- When
- Every day
- Estimated price
- $35–100
- Website
- easyfly.com.co
Flights from Cali to Enrique Olaya Herrera Airport
- Ave. Duration
- 1h 5m
- When
- Every day
- Estimated price
- $120–900
Flights from Cali to Enrique Olaya Herrera Airport via Quibdo
- Ave. Duration
- 2h 32m
- When
- Saturday
- Estimated price
- $130–950
- Website
- avianca.com
Flights from Cali to Medellin Jose Marie Cordova
- Ave. Duration
- 55 min
- When
- Every day
- Estimated price
- $35–130
- Website
- latam.com
Flights from Cali to Medellin Jose Marie Cordova
- Ave. Duration
- 51 min
- When
- Every day
- Estimated price
- $60–440
- Phone
- +57 313 2499101
- [email protected]
- Website
- trejos.co
Bus from Terminal de Transporte Cali to Terminal del Sur
- Ave. Duration
- 7h 45m
- Frequency
- 4 times a day
- Estimated price
- $32
- Schedules at
- pinbus.com
- Book at
- pinbus.com
- Phone
- +57 601 4249090
- [email protected]
- Website
- bolivariano.com.co
Bus from Terminal de Transporte Cali to Terminal del Sur
- Ave. Duration
- 10h
- Frequency
- Every 3 hours
- Estimated price
- $28–40
- Schedules at
- bolivariano.com.co
- Book at
- bolivariano.com.co
- Phone
- +57 318 760 6799
- [email protected]
- Website
- cootrancise.com
Bus from Terminal de Transporte Cali to Terminal Guadalajara de Buga
- Ave. Duration
- 1h
- Frequency
- Every 15 minutes
- Estimated price
- $5
- Schedules at
- cootrancise.com
- Phone
- +57 311 273 0419
- [email protected]
- Website
- expresopalmira.com.co
Bus from Terminal Guadalajara de Buga to Terminal del Norte
- Ave. Duration
- 7h
- Frequency
- 3 times a day
- Estimated price
- $27–40
- Schedules at
- expresopalmira.com.co
- Book at
- expresopalmira.com.co
- Phone
- 01 8000 42 37 87
- [email protected]
- Website
- empresaarauca.com
Bus from Terminal de Transporte Cali to Terminal del Sur
- Ave. Duration
- 8h 30m
- Frequency
- Every 3 hours
- Estimated price
- $30–45
- Schedules at
- empresaarauca.com
- Basico
- $30–45
- Phone
- +57 310 208 2548
- [email protected]
- Website
- flotamagdalena.com
Bus from Terminal de Transporte Cali to Terminal del Sur
- Ave. Duration
- 10h
- Frequency
- 3 times a day
- Estimated price
- $26–40
- Schedules at
- flotamagdalena.com
- Premium
- $30–40
Want to know more about travelling around the world?
Rome2Rio's Travel Guide series provide vital information for the global traveller. Read our range of informative guides on popular transport routes and companies - including Travelling by boat in Italy, Which side of Niagara Falls should I choose (and how do I get there)?, and Travelling to the US: What do I need to know? - to help you get the most out of your next trip.
Booking & Getting There
There are 2804+ hotels available in Antioquia.




















