There are 6 ways to get from Cali to Santa Cruz by plane, bus, car, or shuttle
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Cali
best- Fly from Cali (CLO) to Viru Viru International Airport (VVI)plane CLO - VVI
9h 21m$373–755Drive 4,719.7 km
cheapest- Drive from Cali to Santa Cruz de la Sierracar 4,719.7 km
2d 21h$247–356Bus via Lima
- Take the bus from Terminal de Transporte Cali to Ipialesbus
- Take the bus from Rumichaca to Gran Terminal Terrestre Plaza Nortebus
- Take the bus from Lima - Terminal Arriola to La Pazbus
- Take the bus from La Paz to Santa Cruzbus
3d 19h$265–821Bus to Popayan Airport, fly
- Take the bus from Terminal de Transporte Cali to Terminal Popayánbus
- Fly from Popayan Airport (PPN) to Viru Viru International Airport (VVI)plane PPN - VVI
14h 15m$472–1,819Shuttle to Armenia, fly
- Take a shuttle bus from Terminal de Transporte Cali to Armenia
- Fly from Armenia (AXM) to Viru Viru International Airport (VVI)plane AXM - VVI
13h 7m$263–963Bus
- Take the bus from Terminal de Transporte Cali to Ipialesbus
- Take the bus from Rumichaca to Gran Terminal Terrestre Plaza Nortebus
- Take the bus from Oltursa Lima Terminal to La Pazbus
- Take the bus from La Paz to Santa Cruzbus
3d 19h$296–414
Cali (CLO) to Viru Viru International Airport (VVI) flights
Comparing Your Travel Options
The cheapest way to get from Cali to Santa Cruz is to drive which costs $240 - $360 and takes 2 days 21h.
The fastest way to get from Cali to Santa Cruz is to fly which takes 9h 21m and costs $370 - $800.
No, there is no direct bus from Cali to Santa Cruz. However, there are services departing from Terminal de Transporte Cali and arriving at Santa Cruz via Terminal Ipiales, Rumichaca, Gran Terminal Terrestre Plaza Norte, Lima - Terminal Arriola and La Paz. The journey, including transfers, takes approximately 3 days 19h.
The distance between Cali and Santa Cruz is 2807 km. The road distance is 4719.7 km.
The best way to get from Cali to Santa Cruz without a car is to bus via Lima which takes 3 days 19h and costs $260 - $850.
It takes approximately 9h 21m to get from Cali to Santa Cruz, including transfers.
Cali to Santa Cruz bus services, operated by Bolivariano, depart from Terminal de Transporte Cali station.
The best way to get from Cali to Santa Cruz is to fly which takes 9h 21m and costs $370 - $800. Alternatively, you can bus via Lima, which costs $260 - $850 and takes 3 days 19h.
Cali to Santa Cruz bus services, operated by Bolivariano, arrive at Ipiales station.
Santa Cruz is 1h ahead of Cali. It is currently 5:24 AM in Cali and 6:24 AM in Santa Cruz.
What companies run services between Cali, Colombia and Santa Cruz, Bolivia?
Avianca - Aerovías del Continente Americano S.A., Copa Airlines, and AeroRepública fly from Cali (CLO) to Viru Viru International Airport (VVI) 5 times a day. Alternatively, you can take a bus from Terminal de Transporte Cali to Santa Cruz de la Sierra via Ipiales, Terminal Ipiales, Rumichaca, Gran Terminal Terrestre Plaza Norte, Lima Nicolas Arriola, Lima - Terminal Arriola, La Paz, and Santa Cruz in around 3d 19h.
- Website
- avianca.com
Flights from Cali to Viru Viru International Airport via Bogota
- Ave. Duration
- 6h 38m
- When
- Every day
- Estimated price
- $330–1,300
Flights from Cali to Viru Viru International Airport via Pasto, Bogota
- Ave. Duration
- 10h 35m
- When
- Every day
- Estimated price
- $350–1,300
Flights from Cali to Viru Viru International Airport via Medellin Jose Marie Cordova, Bogota
- Ave. Duration
- 10h 45m
- When
- Monday, Tuesday, Wednesday, Friday, Saturday, and Sunday
- Estimated price
- $340–1,300
Flights from Popayan Airport to Viru Viru International Airport via Bogota
- Ave. Duration
- 11h
- When
- Every day
- Estimated price
- $460–1,800
Flights from Armenia to Viru Viru International Airport via Bogota
- Ave. Duration
- 7h 21m
- When
- Every day
- Estimated price
- $250–950
Flights from Armenia to Viru Viru International Airport via Medellin Jose Marie Cordova, Bogota
- Ave. Duration
- 10h 10m
- When
- Every day
- Estimated price
- $260–950
- Phone
- +57 601 4249090
- [email protected]
- Website
- bolivariano.com.co
Bus from Terminal de Transporte Cali to Ipiales
- Ave. Duration
- 12h
- Frequency
- Every 3 hours
- Estimated price
- $24–45
- Schedules at
- bolivariano.com.co
- Book at
- bolivariano.com.co
Bus from Terminal de Transporte Cali to Ipiales
- Ave. Duration
- 12h
- Frequency
- Every 3 hours
- Estimated price
- $24–45
- Schedules at
- bolivariano.com.co
- Book at
- bolivariano.com.co
Want to know more about travelling around the world?
Rome2Rio's Travel Guide series provide vital information for the global traveller. Read our range of informative guides on popular transport routes and companies - including How to travel India's Golden Triangle, Want to know more about Flixbus?, and What documents do I need to cross Niagara Falls? - to help you get the most out of your next trip.
Booking & Getting There
Yes, the driving distance between Cali to Santa Cruz is 4720 km. It takes approximately 2 days 21h to drive from Cali to Santa Cruz.
There are 745+ hotels available in Santa Cruz.



