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How to get fromCali to Santa Cruzby plane, bus, car, or shuttle

Find Transport to Santa Cruz

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There are 6 ways to get from Cali to Santa Cruz by plane, bus, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Cali

    best
    1. Fly from Cali (CLO) to Viru Viru International Airport (VVI)plane plane CLO - VVI
    9h 20m
    $383–755

  2. Bus

    cheapest
    1. Take the bus from Terminal de Transporte Cali to Ipialesbus bus
    2. Take the bus from Tulcán to Terminal Terrestre Quitumbebus bus
    3. Take the bus from Terminal Terrestre Quitumbe to Lima Javier Pradobus bus
    4. Take the bus from Oltursa Lima Terminal to La Pazbus bus
    5. Take the bus from La Paz to Santa Cruzbus bus
    4d 8h
    $184–301

  3. Bus via Lima

    1. Take the bus from Terminal de Transporte Cali to Ipialesbus bus
    2. Take the bus from Tulcán to Terminal Terrestre Quitumbebus bus
    3. Take the bus from Terminal Terrestre Quitumbe to Lima Plaza Nortebus bus
    4. Take the bus from Lima - Terminal Arriola to La Pazbus bus
    5. Take the bus from La Paz to Santa Cruzbus bus
    4d 7h
    $196–763

  4. Drive  4,726.9 km

    1. Drive from Cali to Santa Cruz de la Sierracar car 4,726.9 km
    2d 21h
    $562–812

  5. Bus to Popayan Airport, fly

    1. Take the bus from Terminal de Transporte Cali to Terminal Popayánbus bus
    2. Fly from Popayan Airport (PPN) to Viru Viru International Airport (VVI)plane plane PPN - VVI
    14h 20m
    $452–1,620

  6. Shuttle to Armenia, fly

    1. Take a shuttle bus from Terminal de Transporte Cali to Armeniashuttle bus
    2. Fly from Armenia (AXM) to Viru Viru International Airport (VVI)plane plane AXM - VVI
    13h 17m
    $303–1,113

Cali (CLO) to Viru Viru International Airport (VVI) flights

Calendar24Weekly Planes
Duration8h 12mAverage Duration
Ticket$190Cheapest Price
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Comparing Your Travel Options

Map of how to get from Cali to Santa Cruz.ExpandLaunch map view
  • Distance: 2,807.5 km
  • Duration: 9h 20m

What companies run services between Cali, Colombia and Santa Cruz, Bolivia?

Avianca - Aerovías del Continente Americano S.A., Copa Airlines, and AeroRepública fly from Cali (CLO) to Viru Viru International Airport (VVI) 3 times a day. Alternatively, you can take a bus from Terminal de Transporte Cali to Santa Cruz de la Sierra via Ipiales, Tulcán, Terminal Terrestre Quitumbe, Lima Plaza Norte, Municipalidad Del Rímac, Óvalo Arriola, Lima - Terminal Arriola, La Paz, and Santa Cruz in around 4d 7h.

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