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How to get fromCambridge to Louisvilleby plane, bus (Flixbus), train, bus, car, or bus (Greyhound, Amtrak)

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There are 8 ways to get from Cambridge to Louisville by plane, bus (Flixbus), train, bus, car, or bus (Greyhound, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Boston Logan Airport to Louisville International Airport

    best
    1. Fly from Boston Logan Airport (BOS) to Louisville International Airport (SDF)plane plane BOS - SDF
    5h 11m
    $130–662

  2. Bus via Columbus

    1. Take the bus from Boston to NYC Downtownbus bus
    2. Take the bus from New York, NY to Columbus, OHbus bus Nyc
    3. Take the bus from Columbus - Downtown - Mound St to Louisville, KY Bus Stationbus bus
    21h 16m
    $165–226

  3. Train, bus via Toledo

    1. Take the train from Boston to Toledotrain train
    2. Take the bus from Toledo to Indianapolis, INbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    25h 46m
    $292–623

  4. Drive 935 mi

    1. Drive from Cambridge to Louisvillecar car 935 mi
    16h 51m
    $171–247

  5. Bus to Bradley International Airport, fly to Louisville International Airport

    1. Take the bus from Boston to Hartfordbus bus
    2. Fly from Bradley International Airport (BDL) to Louisville International Airport (SDF)plane plane BDL - SDF
    7h 20m
    $134–661

  6. Fly Boston Logan Airport to Covington, bus

    1. Fly from Boston Logan Airport (BOS) to Covington (CVG)plane plane BOS - CVG
    2. Take the bus from Cincinnati - Downtown to Louisville, KY Bus Stationbus bus
    7h 40m
    $420–1,056

  7. Bus

    1. Take the bus from Boston to Port Authority Bus Terminalbus bus
    2. Take the bus from Port Authority Bus Terminal to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    26h 57m
    $174–342

  8. Train, bus (Amtrak)

    1. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    31h 37m
    $375–1,408

Cambridge to Louisville by bus and foot

Calendar7Weekly Services
Duration21h 16mAverage Duration
Ticket$165Cheapest Price
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Questions & Answers

Map of how to get from Cambridge to Louisville.ExpandLaunch map view
  • Distance: 838.2 mi
  • Duration: 5h 11m

What companies run services between Cambridge, MA, USA and Louisville, KY, USA?

American Airlines, Delta, and two other airlines fly from Boston Logan Airport (BOS) to Louisville International Airport (SDF) every 3 hours. Alternatively, you can take a bus from Boston to Louisville, KY Bus Station via NYC Downtown, New York, NY, Columbus, OH, and Columbus - Downtown - Mound St in around 21h 16m.

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