Rome2Rio

How to get fromCambridge to Chicagoby car, plane, train (Amtrak), bus, train, bus (Flixbus, Greyhound), or shuttle

Find Transport to Chicago

See all options

There are 10 ways to get from Cambridge to Chicago by car, plane, train (Amtrak), bus, train, bus (Flixbus, Greyhound), or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Erie International Airport, fly to Chicago O'Hare International Airport

    best
    1. Drive from Cambridge to Erie-Airport-ERIcar car
    2. Fly from Erie International Airport (ERI) to Chicago O'Hare International Airport (ORD)plane plane ERI - ORD
    6h 11m
    $90–337

  2. Bus

    cheapest
    1. Take the bus from Kitchener to Detroit Bus Stationbus bus FlixBus N2710
    2. Take the bus from Detroit Bus Station to Chicago Bus Stationbus bus Greyhound US0160
    14h 31m
    $74–144

  3. Train

    1. Take the train from Kitchener to Sarniatrain train VIA Rail
    2. Take the train from Port Huron Station to Chicago Union Stationtrain train Blue Water
    12h 57m
    $135–397

  4. Bus, train

    1. Take the bus from Kitchener, ON - Sportsworld Station to London, ON - VIA Railbus bus
    2. Take the bus from London to Detroit Bus Stationbus bus
    3. Take the train from Detroit to Chicago Union Stationtrain train
    13h 56m
    $133–254

  5. Bus to Toronto Pearson International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Kitchener, ON - Sportsworld Station to Pearson International Airport Terminal 1bus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Chicago O'Hare International Airport (ORD)plane plane YYZ - ORD
    6h 58m
    $351–1,130

  6. Bus to Toronto Island Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Kitchener, ON - Sportsworld Station to Toronto, ON - 44 York St.bus bus
    2. Fly from Toronto Island Airport (YTZ) to Chicago O'Hare International Airport (ORD)plane plane YTZ - ORD
    7h 42m
    $202–1,332

  7. Bus, shuttle to Buffalo Niagara International Airport, fly to Chicago Midway International Airport

    1. Take the bus from Kitchener, ON - Sportsworld Station to Pearson International Airport Terminal 1bus bus
    2. Take a shuttle bus from Pearson International Airport Terminal 1 to Buffalo Airportshuttle bus
    3. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane plane BUF - MDW
    8h 4m
    $271–520

  8. Bus to Toronto Island Airport, fly to Chicago Midway International Airport

    1. Take the bus from Kitchener, ON - Sportsworld Station to Toronto, ON - 44 York St.bus bus
    2. Fly from Toronto Island Airport (YTZ) to Chicago Midway International Airport (MDW)plane plane YTZ - MDW
    7h 33m
    $162–462

  9. Bus, shuttle to Buffalo Niagara International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Kitchener, ON - Sportsworld Station to Pearson International Airport Terminal 1bus bus
    2. Take a shuttle bus from Pearson International Airport Terminal 1 to Buffalo Airportshuttle bus
    3. Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane plane BUF - ORD
    8h 27m
    $281–450

  10. Drive 456.3 mi

    1. Drive from Cambridge to Chicagocar car 456.3 mi
    7h 39m
    $105–151

Cambridge to Chicago by bus, tram, foot, train, and car

Calendar7Weekly Services
Duration12h 57mAverage Duration
Ticket$135Cheapest Price
See schedules

Questions & Answers

Map of how to get from Cambridge to Chicago.ExpandLaunch map view
  • Distance: 600.2 mi
  • Duration: 6h 11m

What companies run services between Cambridge, ON, Canada and Chicago, IL, USA?

You can take a bus from Wellington / Main to Chicago Union Station via Fairway Station, Fairway Station - Northbound, Central Station - Northbound, Kitchener, Sarnia, and Port Huron Station in around 12h 57m. Alternatively, you can take a bus from Wellington / Main to Chicago Bus Station via Fairway Station, Victoria / Duke, Kitchener, and Detroit Bus Station in around 14h 31m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers