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How to get fromCape Cod to Florenceby bus, plane, train, bus (Flixbus), car, or bus (Greyhound)

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There are 11 ways to get from Cape Cod to Florence by bus, plane, train, bus (Flixbus), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Boston Logan Airport, fly to Charleston International Airport, train

    best
    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Charleston International Airport (CHS)plane plane BOS - CHS
    3. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    11h 3m
    $656–1,049

  2. Bus

    cheapest
    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to NYC Downtownbus bus
    3. Take the bus from New York, NY to Florence, SCbus bus Nyc
    21h 26m
    $142–215

  3. Bus, train

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Florence Stationtrain train
    22h 52m
    $237–1,155

  4. Drive  872.4 mi

    1. Drive from Cape Cod to Florencecar car 872.4 mi
    15h 57m
    $160–230

  5. Bus to Boston Logan Airport, fly to Charlotte Douglas International Airport, bus

    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Charlotte Douglas International Airport (CLT)plane plane BOS - CLT
    3. Take the bus from Charlotte Bus Station to Camdenbus bus
    4. Take the bus from Camden to Florence Bus Stationbus bus
    11h 37m
    $191–458

  6. Bus to Boston Logan Airport, fly to Wilmington International Airport, bus, train

    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Wilmington International Airport (ILM)plane plane BOS - ILM
    3. Take the bus from Wilmington Cape Fear Public Transit to Fayetteville Bus Stationbus bus
    4. Take the train from Fayetteville Amtrak Station to Florence Stationtrain train
    12h 20m
    $166–597

  7. Bus to Boston Logan Airport, fly to Myrtle Beach, bus, train

    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Myrtle Beach (MYR)plane plane BOS - MYR
    3. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    4. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    12h 9m
    $148–524

  8. Bus to Boston Logan Airport, fly to Raleigh-Durham International Airport, train

    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Raleigh-Durham International Airport (RDU)plane plane BOS - RDU
    3. Take the train from Raleigh Union Station to Selma Stationtrain train
    4. Take the train from Selma Station to Florence Stationtrain train
    12h 37m
    $208–1,035

  9. Bus, train to Theodore Francis Green State Airport, fly to Charlotte Douglas International Airport

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the train from South Station to TF Green Airporttrain train
    3. Fly from Theodore Francis Green State Airport (PVD) to Charlotte Douglas International Airport (CLT)plane plane PVD - CLT
    4. Take the bus from Charlotte Bus Station to Camdenbus bus
    5. Take the bus from Camden to Florence Bus Stationbus bus
    13h 39m
    $159–639

  10. Bus, train to Theodore Francis Green State Airport, fly to Myrtle Beach, train

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the train from South Station to TF Green Airporttrain train
    3. Fly from Theodore Francis Green State Airport (PVD) to Myrtle Beach (MYR)plane plane PVD - MYR
    4. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    5. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    14h 14m
    $196–405

  11. Bus via Raleigh

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to Port Authority Bus Terminalbus bus
    3. Take the bus from Port Authority Bus Terminal to Raleigh Bus Stationbus bus
    4. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus
    22h 48m
    $160–270

Cape Cod to Florence by bus and train

Calendar14Weekly Services
Duration22h 52mAverage Duration
Ticket$237Cheapest Price
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Comparing Your Travel Options

Map of how to get from Cape Cod to Florence.ExpandLaunch map view
  • Distance: 1,012 mi
  • Duration: 11h 3m

What companies run services between Cape Cod, MA, USA and Florence, SC, USA?

You can take a bus from Town Hall Lawton Bus Shelter to Florence, SC via Hyannis Transportation Center, Boston, South Station, Boston, NYC Downtown, and New York, NY in around 21h 26m.

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