There are 8 ways to get from Cape Cod to Greenville by plane, bus (Flixbus), bus, train, car, taxi, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Barnstable Municipal Airport to Greenville–Spartanburg International Airport
best- Fly from Barnstable Municipal Airport (HYA) to Greenville–Spartanburg International Airport (GSP)plane HYA - GSP
7h 8m$176–796Drive 949.6 mi
cheapest- Drive from Cape Cod to Greenvillecar 949.6 mi
17h 51m$174–251Bus
- Take the bus from Hyannis Transportation Center to Boston South Busesbus
- Take the bus from Boston to NYC Downtownbus
- Take the bus from New York, NY to Gastonia, NC - Chester St.bus Nyc
- Take the bus from Los Arcos Restaurant - Gastonia to Taqueria Guadalajara - Greenvillebus
21h 42m$179–274Bus, train
- Take the bus from Hyannis Transportation Center to Boston South Busesbus
- Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain
- Take the train from Ny Moynihan Train Hall At Penn Station to Charlotte Amtrak Stationtrain
- Take the bus from Charlotte to Taqueria Guadalajara - Greenvillebus
25h 7m$446–1,402Bus to Boston Logan Airport, fly to Asheville Regional Airport, taxi
- Take the bus from Hyannis to Bostonbus
- Fly from Boston Logan Airport (BOS) to Asheville Regional Airport (AVL)plane BOS - AVL
- Take the taxi from Asheville-Airport-AVL to Greenvilletaxi
7h 25m$240–656Bus to Boston Logan Airport, fly to Greenville–Spartanburg International Airport
- Take the bus from Hyannis to Bostonbus
- Fly from Boston Logan Airport (BOS) to Greenville–Spartanburg International Airport (GSP)plane BOS - GSP
8h 25m$180–821Bus, train to Theodore Francis Green State Airport, fly to Greenville–Spartanburg International Airport
- Take the bus from Hyannis to Bostonbus
- Take the train from South Station to TF Green Airporttrain
- Fly from Theodore Francis Green State Airport (PVD) to Greenville–Spartanburg International Airport (GSP)plane PVD - GSP
9h 17m$198–886Bus via Atlanta
- Take the bus from Hyannis Transportation Center to Boston South Busesbus
- Take the bus from Boston to Port Authority Bus Terminalbus
- Take the bus from Port Authority Bus Terminal to Atlanta Bus Stationbus
- Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus
33h 38m$270–407
Barnstable Municipal Airport (HYA) to Greenville–Spartanburg International Airport (GSP) flights
Comparing Your Travel Options
The cheapest way to get from Cape Cod to Greenville is to drive which costs $170 - $250 and takes 17h 51m.
The fastest way to get from Cape Cod to Greenville is to fly which takes 7h 8m and costs $170 - $800.
No, there is no direct bus from Cape Cod to Greenville. However, there are services departing from Town Hall Lawton Bus Shelter and arriving at Taqueria Guadalajara - Greenville via Hyannis Transportation Center, Boston, New York, NY and Los Arcos Restaurant - Gastonia. The journey, including transfers, takes approximately 21h 42m.
The distance between Cape Cod and Greenville is 821 miles. The road distance is 955.2 miles.
The best way to get from Cape Cod to Greenville without a car is to bus which takes 21h 42m and costs $170 - $280.
It takes approximately 7h 8m to get from Cape Cod to Greenville, including transfers.
Cape Cod to Greenville bus services, operated by Plymouth & Brockton, depart from Hyannis Transportation Center station.
The best way to get from Cape Cod to Greenville is to fly which takes 7h 8m and costs $170 - $800. Alternatively, you can bus, which costs $170 - $280 and takes 21h 42m.
Cape Cod to Greenville bus services, operated by Plymouth & Brockton, arrive at Boston South Buses station.
Yes, the driving distance between Cape Cod to Greenville is 955 miles. It takes approximately 17h 51m to drive from Cape Cod to Greenville.
What companies run services between Cape Cod, MA, USA and Greenville, SC, USA?
American Airlines flies from Barnstable Municipal Airport (HYA) to Greenville–Spartanburg International Airport (GSP) 3 times a day. Alternatively, you can take a bus from Town Hall Lawton Bus Shelter to Greenville via Hyannis Transportation Center, Boston, South Station, Boston, NYC Downtown, New York, NY, Gastonia, NC - Chester St., Los Arcos Restaurant - Gastonia, and Taqueria Guadalajara - Greenville in around 21h 42m.
- Website
- aa.com
Flights from Barnstable Municipal Airport to Greenville–Spartanburg International Airport via Philadelphia
- Ave. Duration
- 5h 50m
- When
- Every day
- Estimated price
- $140–750
Flights from Barnstable Municipal Airport to Greenville–Spartanburg International Airport via Chicago O'Hare
- Ave. Duration
- 8h
- When
- Saturday
- Estimated price
- $210–1,000
Flights from Barnstable Municipal Airport to Greenville–Spartanburg International Airport via New York La Guardia
- Ave. Duration
- 9h 15m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $140–750
Flights from Boston Logan Airport to Asheville Regional Airport via Charlotte
- Ave. Duration
- 4h 31m
- When
- Every day
- Estimated price
- $90–470
Flights from Boston Logan Airport to Asheville Regional Airport via Philadelphia
- Ave. Duration
- 4h 37m
- When
- Every day
- Estimated price
- $85–460
Flights from Boston Logan Airport to Asheville Regional Airport via Reagan Washington
- Ave. Duration
- 4h 52m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $85–460
Flights from Boston Logan Airport to Greenville–Spartanburg International Airport via Philadelphia
- Ave. Duration
- 5h 1m
- When
- Every day
- Estimated price
- $130–750
Flights from Boston Logan Airport to Greenville–Spartanburg International Airport via Charlotte
- Ave. Duration
- 5h
- When
- Every day
- Estimated price
- $140–750
Flights from Boston Logan Airport to Greenville–Spartanburg International Airport via Reagan Washington
- Ave. Duration
- 5h 47m
- When
- Every day
- Estimated price
- $130–750
Flights from Theodore Francis Green State Airport to Greenville–Spartanburg International Airport via Reagan Washington
- Ave. Duration
- 4h 37m
- When
- Every day
- Estimated price
- $140–800
Flights from Theodore Francis Green State Airport to Greenville–Spartanburg International Airport via Charlotte
- Ave. Duration
- 4h 50m
- When
- Every day
- Estimated price
- $140–800
Flights from Theodore Francis Green State Airport to Greenville–Spartanburg International Airport via Philadelphia
- Ave. Duration
- 4h 45m
- When
- Every day
- Estimated price
- $140–800
- Website
- united.com
Flights from Boston Logan Airport to Asheville Regional Airport via Newark
- Ave. Duration
- 4h 24m
- When
- Thursday to Saturday
- Estimated price
- $85–460
Flights from Boston Logan Airport to Greenville–Spartanburg International Airport via Washington Dulles
- Ave. Duration
- 4h 34m
- When
- Every day
- Estimated price
- $130–750
Flights from Boston Logan Airport to Greenville–Spartanburg International Airport via Newark
- Ave. Duration
- 4h 56m
- When
- Every day
- Estimated price
- $130–750
- Website
- southwest.com
Flights from Boston Logan Airport to Greenville–Spartanburg International Airport via Baltimore
- Ave. Duration
- 4h 13m
- When
- Every day
- Estimated price
- $130–750
Flights from Theodore Francis Green State Airport to Greenville–Spartanburg International Airport via Baltimore
- Ave. Duration
- 4h 1m
- When
- Every day
- Estimated price
- $140–800
- Website
- delta.com
Flights from Boston Logan Airport to Asheville Regional Airport
- Ave. Duration
- 2h 33m
- When
- Saturday and Sunday
- Estimated price
- $85–460
Flights from Boston Logan Airport to Asheville Regional Airport via New York La Guardia
- Ave. Duration
- 4h 37m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $85–460
Flights from Boston Logan Airport to Asheville Regional Airport via Atlanta
- Ave. Duration
- 4h 50m
- When
- Every day
- Estimated price
- $110–550
- Website
- flybreeze.com
Flights from Theodore Francis Green State Airport to Greenville–Spartanburg International Airport
- Ave. Duration
- 2h 33m
- When
- Tuesday, Thursday, and Sunday
- Estimated price
- $270–1,700
Flights from Theodore Francis Green State Airport to Greenville–Spartanburg International Airport via Pittsburgh
- Ave. Duration
- 5h 13m
- When
- Thursday and Sunday
- Estimated price
- $290–1,700
- Website
- allegiantair.com
Flights from Boston Logan Airport to Asheville Regional Airport
- Ave. Duration
- 2h 23m
- When
- Friday and Monday
- Estimated price
- $85–460
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Boston to Ny Moynihan Train Hall At Penn Station
- Ave. Duration
- 4h 2m
- Frequency
- Every 3 hours
- Estimated price
- $120–200
- Website
- Amtrak
Train from Ny Moynihan Train Hall At Penn Station to Charlotte Amtrak Station
- Ave. Duration
- 12h 30m
- Frequency
- Twice daily
- Estimated price
- $330–550
- Website
- Amtrak
Rome2Rio's guide to Amtrak Acela
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Boston to Ny Moynihan Train Hall At Penn Station
- Ave. Duration
- 3h 49m
- Frequency
- Every 4 hours
- Estimated price
- $50–750
- Schedules at
- Amtrak Acela
- Website
- Amtrak
- Business Class
- $50–490
- First Class
- $200–750
Train from South Station to TF Green Airport
- Ave. Duration
- 1h 30m
- Frequency
- Every 4 hours
- Estimated price
- $9–16
- Website
- Massachusetts Bay Transportation Authority
- Website
- MBTA: World Cup 2026
- Adult
- $9–16
- Phone
- +1 (508) 746-0378
- [email protected]
- Website
- Plymouth & Brockton
Bus from Hyannis Transportation Center to Boston South Buses
- Ave. Duration
- 1h 50m
- Frequency
- Hourly
- Estimated price
- $27–35
- Website
- Plymouth & Brockton
- One Way - Adult
- $27–35
Bus from Hyannis Transportation Center to Boston South Buses
- Ave. Duration
- 1h 50m
- Frequency
- Hourly
- Estimated price
- $27–35
- Website
- Plymouth & Brockton
- One Way - Adult
- $27–35
Bus from Hyannis Transportation Center to Boston South Buses
- Ave. Duration
- 1h 50m
- Frequency
- Hourly
- Estimated price
- $27–35
- Website
- Plymouth & Brockton
- One Way - Adult
- $27–35
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Boston to NYC Downtown
- Ave. Duration
- 5h
- Frequency
- Every 4 hours
- Estimated price
- $30–50
- Schedules at
- Flixbus USA
- Phone
- +1 646-630-7186
- [email protected]
- Website
- Wanda Coach
Bus from New York, NY to Gastonia, NC - Chester St.
- Ave. Duration
- 8h 30m
- Frequency
- 3 times a day
- Estimated price
- $90–130
- Website
- Wanda Coach
- Book at
- GotoBus.com
- Adult One Way
- $90–130
- Phone
- +1 888 358 6762
- [email protected]
- Website
- Tornado Bus Company
Bus from Los Arcos Restaurant - Gastonia to Taqueria Guadalajara - Greenville
- Ave. Duration
- 1h 57m
- Frequency
- Once daily
- Estimated price
- $17–40
- Schedules at
- Tornado Bus Company
- Adult
- $17–40
Bus from Charlotte to Taqueria Guadalajara - Greenville
- Ave. Duration
- 2h 27m
- Frequency
- Once daily
- Estimated price
- $23–45
- Schedules at
- Tornado Bus Company
- Adult
- $23–45
Bus from Atlanta to Taqueria Guadalajara - Greenville
- Ave. Duration
- 3h 22m
- Frequency
- Once daily
- Estimated price
- $30–50
- Schedules at
- Tornado Bus Company
- Adult
- $30–50
- Phone
- 1-800-343-9999
- Website
- Peter Pan
Bus from Hyannis to Boston
- Ave. Duration
- 1h 40m
- Frequency
- Every 3 hours
- Estimated price
- $15–26
- Website
- Peter Pan
Bus from Hyannis to Boston
- Ave. Duration
- 1h 40m
- Frequency
- Every 3 hours
- Estimated price
- $15–26
- Website
- Peter Pan
Bus from Hyannis to Boston
- Ave. Duration
- 1h 30m
- Frequency
- Every 3 hours
- Estimated price
- $14–25
- Website
- Peter Pan
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Boston to Port Authority Bus Terminal
- Ave. Duration
- 4h 50m
- Frequency
- Hourly
- Estimated price
- $35–60
- Website
- Greyhound
Bus from Port Authority Bus Terminal to Atlanta Bus Station
- Ave. Duration
- 18h 45m
- Frequency
- 4 times a day
- Estimated price
- $160–240
- Website
- Greyhound
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide
Booking & Getting There
There are 229+ hotels available in Greenville.


















