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How to get fromCape Cod to Lexingtonby plane, bus, train, car, bus (Flixbus), or bus (Greyhound)

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There are 9 ways to get from Cape Cod to Lexington by plane, bus, train, car, bus (Flixbus), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Barnstable Municipal Airport to Columbia

    best
    1. Fly from Barnstable Municipal Airport (HYA) to Columbia (CAE)plane plane HYA - CAE
    7h 30m
    $264–1,241

  2. Drive 961.2 mi

    cheapest
    1. Drive from Cape Cod to Lexingtoncar car 961.2 mi
    17h 24m
    $176–254

  3. Bus, train

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Columbia, SCbus bus Nyc
    23h 39m
    $208–971

  4. Train, bus

    1. Take the train from Hyannis to South Stationtrain train
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Charlotte Amtrak Stationtrain train
    4. Take the bus from Charlotte Bus Station to Camdenbus bus
    5. Take the bus from Camden to Columbia, SCbus bus Nyc
    26h 43m
    $329–1,293

  5. Bus to Boston Logan Airport, fly to Columbia

    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Columbia (CAE)plane plane BOS - CAE
    8h 30m
    $259–1,078

  6. Bus to Boston Logan Airport, fly to Charleston International Airport, drive

    1. Take the bus from Hyannis Transportation Center to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Charleston International Airport (CHS)plane plane BOS - CHS
    3. Drive from Charleston-Airport-CHS to Lexingtoncar car
    8h 31m
    $651–1,023

  7. Bus, train to Theodore Francis Green State Airport, fly to Columbia

    1. Take the bus from Hyannis Transportation Center to Boston South Stationbus bus
    2. Take the train from South Station to TF Green Airporttrain train
    3. Fly from Theodore Francis Green State Airport (PVD) to Columbia (CAE)plane plane PVD - CAE
    11h 8m
    $235–1,044

  8. Bus

    1. Take the bus from Hyannis Transportation Center to Boston South Busesbus bus
    2. Take the bus from Boston to NYC Downtownbus bus
    3. Take the bus from New York, NY to Columbia, SCbus bus Nyc
    24h 23m
    $185–273

  9. Bus via Charlotte

    1. Take the bus from Hyannis Transportation Center to Providence Bus Terminalbus bus
    2. Take the bus from Peter Pan Bus Terminal to Port Authority Bus Terminalbus bus
    3. Take the bus from Port Authority Bus Terminal to Charlotte Bus Stationbus bus
    4. Take the bus from Charlotte Bus Station to Camdenbus bus
    5. Take the bus from Camden to Columbia, SCbus bus Nyc
    26h 59m
    $223–452

Barnstable Municipal Airport (HYA) to Columbia (CAE) flights

Calendar13Weekly Planes
Duration6h 44mAverage Duration
Ticket$237Cheapest Price
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Questions & Answers

Map of how to get from Cape Cod to Lexington.ExpandLaunch map view
  • Distance: 810.8 mi
  • Duration: 7h 30m

What companies run services between Cape Cod, MA, USA and Lexington, SC, USA?

American Airlines flies from Barnstable Municipal Airport (HYA) to Columbia (CAE) twice daily. Alternatively, you can take a bus from Town Hall Lawton Bus Shelter to Lexington via Hyannis Transportation Center, Boston, Bus Terminal South Station, Boston, NYC Downtown, New York, NY, and Columbia, SC in around 24h 23m.

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