There are 7 ways to get from Cape Cod to San Diego by plane, bus, train, bus (Greyhound, Flixbus, Amtrak), car, or taxi
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Barnstable Municipal Airport
best- Fly from Barnstable Municipal Airport (HYA) to San Diego International Airport (SAN)plane HYA - SAN
11h 1m$221–901Bus to Boston Logan Airport, fly
cheapest- Take the bus from Hyannis to Bostonbus
- Fly from Boston Logan Airport (BOS) to San Diego International Airport (SAN)plane BOS - SAN
10h 19m$154–426Bus, train
- Take the bus from Hyannis Transportation Center to Boston South Busesbus
- Take the train from Boston to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain
- Take the train from Fullerton Amtrak Station to San Diegotrain
3d 1h$1,832–2,925Bus
- Take the bus from Hyannis Transportation Center to Boston South Busesbus
- Take the bus from Boston to Newark Penn Stationbus
- Take the bus from Newark Penn Station to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Los Angeles Union Stationbus
- Take the bus from Los Angeles to San Diegobus
3d 5hDrive 2,987.6 mi
- Drive from Cape Cod to San Diegocar 2,987.6 mi
2d 2h$528–763Taxi to Provincetown Municipal Airport, fly
- Take the taxi from Cape Cod to Provincetown Municipal Airport (PVC)taxi
- Fly from Provincetown Municipal Airport (PVC) to San Diego International Airport (SAN)plane PVC - SAN
9h 3m$472–1,480Bus, train to Theodore Francis Green State Airport, fly
- Take the bus from Hyannis to Bostonbus
- Take the train from South Station to TF Green Airporttrain
- Fly from Theodore Francis Green State Airport (PVD) to San Diego International Airport (SAN)plane PVD - SAN
14h 26m$213–791
Cape Cod to San Diego by bus and train
Comparing Your Travel Options
The cheapest way to get from Cape Cod to San Diego is to bus and fly which costs $150 - $430 and takes 10h 19m.
The fastest way to get from Cape Cod to San Diego is to taxi and fly which takes 9h 3m and costs $470 - $1,500.
No, there is no direct bus from Cape Cod to San Diego. However, there are services departing from Town Hall Lawton Bus Shelter and arriving at San Diego via Hyannis Transportation Center, Boston, Newark Penn Station, St Louis Bus Station and Los Angeles. The journey, including transfers, takes approximately 3 days 5h.
The distance between Cape Cod and San Diego is 2643 miles. The road distance is 3005.1 miles.
The best way to get from Cape Cod to San Diego without a car is to bus and train which takes 3 days 1h and costs $1,800 - $3,000.
It takes approximately 11h 1m to get from Cape Cod to San Diego, including transfers.
Cape Cod to San Diego bus services, operated by Plymouth & Brockton, depart from Hyannis Transportation Center station.
The best way to get from Cape Cod to San Diego is to fly which takes 11h 1m and costs $220 - $900. Alternatively, you can bus, which costs and takes 3 days 5h.
Cape Cod to San Diego bus services, operated by Plymouth & Brockton, arrive at Boston South Buses station.
Yes, the driving distance between Cape Cod to San Diego is 3005 miles. It takes approximately 2 days 2h to drive from Cape Cod to San Diego.
What companies run services between Cape Cod, MA, USA and San Diego, CA, USA?
American Airlines, Cape Air, and JetBlue Airways fly from Barnstable Municipal Airport (HYA) to San Diego International Airport (SAN) 4 times a day. Alternatively, you can take a bus from Town Hall Lawton Bus Shelter to San Diego via Hyannis Transportation Center, Boston, South Station, Boston, Newark Penn Station, St Louis Bus Station, Los Angeles Union Station, and Los Angeles in around 3d 5h.
- Website
- southwest.com
Flights from Boston Logan Airport to San Diego International Airport
- Ave. Duration
- 6h 25m
- When
- Every day
- Estimated price
- $200–800
Flights from Boston Logan Airport to San Diego International Airport via Denver
- Ave. Duration
- 8h
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $200–800
Flights from Boston Logan Airport to San Diego International Airport via St. Louis
- Ave. Duration
- 8h 10m
- When
- Tuesday and Wednesday
- Estimated price
- $200–800
Flights from Boston Logan Airport to San Diego International Airport via Chicago Midway
- Ave. Duration
- 8h 27m
- When
- Monday, Thursday, Friday, Sunday, Tuesday, and Wednesday
- Estimated price
- $200–800
Flights from Provincetown Municipal Airport to San Diego International Airport via Boston Logan Airport
- Ave. Duration
- 7h 55m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $320–1,300
Flights from Theodore Francis Green State Airport to San Diego International Airport via Chicago Midway
- Ave. Duration
- 8h 30m
- When
- Every day
- Estimated price
- $190–750
Flights from Theodore Francis Green State Airport to San Diego International Airport via Denver
- Ave. Duration
- 8h
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $190–750
Flights from Theodore Francis Green State Airport to San Diego International Airport via Nashville
- Ave. Duration
- 9h 20m
- When
- Monday, Thursday, Friday, Sunday, Tuesday, and Wednesday
- Estimated price
- $190–800
- Website
- aa.com
Flights from Barnstable Municipal Airport to San Diego International Airport via Philadelphia
- Ave. Duration
- 10h 52m
- When
- Every day
- Estimated price
- $230–900
Flights from Barnstable Municipal Airport to San Diego International Airport via Chicago O'Hare
- Ave. Duration
- 11h 54m
- When
- Saturday
- Estimated price
- $220–900
Flights from Boston Logan Airport to San Diego International Airport
- Ave. Duration
- 6h 31m
- When
- Every day
- Estimated price
- $140–400
Flights from Boston Logan Airport to San Diego International Airport via Phoenix
- Ave. Duration
- 8h 12m
- When
- Every day
- Estimated price
- $200–800
Flights from Provincetown Municipal Airport to San Diego International Airport via Boston Logan Airport
- Ave. Duration
- 8h 20m
- When
- Monday and Sunday
- Estimated price
- $420–1,600
Flights from Provincetown Municipal Airport to San Diego International Airport via Boston Logan Airport, Phoenix
- Ave. Duration
- 10h 54m
- When
- Monday, Sunday, Thursday, Friday, and Saturday
- Estimated price
- $320–1,300
- Website
- jetblue.com
Flights from Barnstable Municipal Airport to San Diego International Airport via Boston Logan Airport
- Ave. Duration
- 10h 11m
- When
- Every day
- Estimated price
- $220–900
Flights from Boston Logan Airport to San Diego International Airport
- Ave. Duration
- 6h 25m
- When
- Every day
- Estimated price
- $200–800
Flights from Provincetown Municipal Airport to San Diego International Airport via Boston Logan Airport
- Ave. Duration
- 8h 26m
- When
- Monday and Sunday
- Estimated price
- $320–1,300
- Website
- alaskaair.com
Flights from Boston Logan Airport to San Diego International Airport
- Ave. Duration
- 6h 31m
- When
- Every day
- Estimated price
- $140–400
Flights from Provincetown Municipal Airport to San Diego International Airport via Boston Logan Airport
- Ave. Duration
- 8h 20m
- When
- Monday and Sunday
- Estimated price
- $420–1,600
- Website
- delta.com
Flights from Boston Logan Airport to San Diego International Airport
- Ave. Duration
- 6h 18m
- When
- Every day
- Estimated price
- $200–800
Flights from Theodore Francis Green State Airport to San Diego International Airport via Minneapolis
- Ave. Duration
- 8h 27m
- When
- Every day
- Estimated price
- $190–800
Flights from Theodore Francis Green State Airport to San Diego International Airport via Los Angeles
- Ave. Duration
- 8h 35m
- When
- Monday and Friday
- Estimated price
- $220–1,200
- Website
- united.com
Flights from Provincetown Municipal Airport to San Diego International Airport via Boston Logan Airport, Denver
- Ave. Duration
- 10h 45m
- When
- Monday and Sunday
- Estimated price
- $320–1,300
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Boston to Chicago Union Station
- Ave. Duration
- 22h 22m
- Frequency
- Once daily
- Estimated price
- $550–900
- Website
- Amtrak
Train from Chicago Union Station to Fullerton Amtrak Station
- Ave. Duration
- 42h 44m
- Frequency
- Once daily
- Estimated price
- $1,200–1,900
- Website
- Amtrak
Train from Fullerton Amtrak Station to San Diego
- Ave. Duration
- 2h 26m
- Frequency
- Hourly
- Estimated price
- $55–90
- Website
- Amtrak
Train from South Station to TF Green Airport
- Ave. Duration
- 1h 30m
- Frequency
- Every 4 hours
- Estimated price
- $9–16
- Website
- Massachusetts Bay Transportation Authority
- Website
- MBTA: World Cup 2026
- Adult
- $9–16
- Phone
- +1 (508) 746-0378
- [email protected]
- Website
- Plymouth & Brockton
Bus from Hyannis Transportation Center to Boston South Buses
- Ave. Duration
- 1h 50m
- Frequency
- Hourly
- Estimated price
- $27–35
- Website
- Plymouth & Brockton
- One Way - Adult
- $27–35
Bus from Hyannis Transportation Center to Boston South Buses
- Ave. Duration
- 1h 50m
- Frequency
- Hourly
- Estimated price
- $27–35
- Website
- Plymouth & Brockton
- One Way - Adult
- $27–35
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Boston to Newark Penn Station
- Ave. Duration
- 5h 20m
- Frequency
- 4 times a day
- Estimated price
- $45–75
- Website
- Greyhound
Bus from Newark Penn Station to St Louis Bus Station
- Ave. Duration
- 21h 45m
- Frequency
- Once daily
- Estimated price
- $180–270
- Website
- Greyhound
Bus from St Louis Bus Station to Los Angeles Union Station
- Ave. Duration
- 40h 30m
- Frequency
- Once daily
- Estimated price
- $350–550
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Boston to Newark Penn Station
- Ave. Duration
- 4h 50m
- Frequency
- 3 times a day
- Estimated price
- $40–65
- Schedules at
- Flixbus USA
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from Los Angeles to San Diego
- Ave. Duration
- 3h
- Frequency
- Once daily
- Website
- Amtrak
- Phone
- 1-800-343-9999
- Website
- Peter Pan
Bus from Hyannis to Boston
- Ave. Duration
- 1h 40m
- Frequency
- Every 3 hours
- Estimated price
- $14–26
- Website
- Peter Pan
Bus from Hyannis to Boston
- Ave. Duration
- 1h 30m
- Frequency
- Every 3 hours
- Estimated price
- $14–25
- Website
- Peter Pan
- Ave. Duration
- 1h 8m
- Estimated price
- $150–180
Barnstable Taxi and Livery
- Phone
- +1 508-524-8818
Town Taxi of Cape Cod
- Phone
- +1 508-775-5555
- Website
- towntaxicapecod.com
Cape Taxi
- Phone
- +1 508 790 0222
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide
Booking & Getting There
There are 2390+ hotels available in San Diego.
















