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How to get fromCape Coral to Florida Keysby car, bus, or plane

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There are 5 ways to get from Cape Coral to Florida Keys by car, bus, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive 274.7 mi

    best
    1. Drive from Cape Coral to Key Westcar car 274.7 mi
    5h 56m
    $51–73

  2. Bus to Miami International Airport, fly

    1. Take the bus from Fort Myers Bus Stop to Miami Airport Stationbus bus
    2. Fly from Miami International Airport (MIA) to Key West International Airport (EYW)plane plane MIA - EYW
    7h 1m
    $52–253

  3. Bus to Tampa, fly

    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Key West International Airport (EYW)plane plane TPA - EYW
    8h 33m
    $98–431

  4. Bus to Orlando, fly

    1. Take the bus from Fort Myers Bus Stop to Orlandobus bus
    2. Fly from Orlando (MCO) to Key West International Airport (EYW)plane plane MCO - EYW
    10h 36m
    $104–715

  5. Bus to Saint Petersburg–Clearwater International Airport, fly

    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus
    2. Fly from Saint Petersburg–Clearwater International Airport (PIE) to Key West International Airport (EYW)plane plane PIE - EYW
    9h 45m
    $58–284

Miami International Airport (MIA) to Key West International Airport (EYW) flights

Calendar27Weekly Planes
Duration1h 4mAverage Duration
Ticket$26Cheapest Price
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Questions & Answers

Map of how to get from Cape Coral to Florida Keys.ExpandLaunch map view
  • Distance: 274.7 mi
  • Duration: 5h 56m

What companies run services between Cape Coral, FL, USA and Florida Keys, Monroe County, FL, USA?

You can drive from Cape Coral to Key West in around 5h 56m.

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Bus operators

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