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How to get fromCape Coral to Knoxvilleby plane, bus, train, bus (Flixbus), car, or taxi

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There are 8 ways to get from Cape Coral to Knoxville by plane, bus, train, bus (Flixbus), car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Ft. Myers to Mcghee Tyson Airport

    best
    1. Fly from Ft. Myers (RSW) to Mcghee Tyson Airport (TYS)plane plane RSW - TYS
    7h 9m
    $208–875

  2. Drive 760.6 mi

    cheapest
    1. Drive from Cape Coral to Knoxvillecar car 760.6 mi
    13h 32m
    $139–201

  3. Bus, train

    1. Take the bus from Fort Myers Bus Stop to Orlandobus bus
    2. Take the train from Kissimmee Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    46h 6m
    $536–978

  4. Bus

    1. Take the bus from Fort Myers Bus Stop to Orlando Bus Stationbus bus
    2. Take the bus from Orlando Bus Station to New York City Chinatownbus bus
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    46h 30m
    $316–478

  5. Taxi to Punta Gorda Airport, fly to Mcghee Tyson Airport

    1. Take the taxi from Cape Coral to Punta Gorda Airport (PGD)taxi taxi
    2. Fly from Punta Gorda Airport (PGD) to Mcghee Tyson Airport (TYS)plane plane PGD - TYS
    2h 47m
    $267–828

  6. Taxi to Punta Gorda Airport, fly to Asheville Regional Airport, drive

    1. Take the taxi from Cape Coral to Punta Gorda Airport (PGD)taxi taxi
    2. Fly from Punta Gorda Airport (PGD) to Asheville Regional Airport (AVL)plane plane PGD - AVL
    3. Drive from Asheville-Airport-AVL to Knoxvillecar car
    4h 41m
    $179–503

  7. Bus to Sarasota–Bradenton International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Fort Myers Bus Stop to Sarasota Cattlemen Transfer Centerbus bus
    2. Fly from Sarasota–Bradenton International Airport (SRQ) to Mcghee Tyson Airport (TYS)plane plane SRQ - TYS
    7h 50m
    $220–946

  8. Bus to Fort Lauderdale–Hollywood International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Fort Myers Bus Stop to Fort Lauderdale International Airportbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Mcghee Tyson Airport (TYS)plane plane FLL - TYS
    7h 31m
    $208–808

Ft. Myers (RSW) to Mcghee Tyson Airport (TYS) flights

Calendar90Weekly Planes
Duration5h 14mAverage Duration
Ticket$154Cheapest Price
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Questions & Answers

Map of how to get from Cape Coral to Knoxville.ExpandLaunch map view
  • Distance: 683.9 mi
  • Duration: 7h 9m

What companies run services between Cape Coral, FL, USA and Knoxville, TN, USA?

Delta, American Airlines, and two other airlines fly from Ft. Myers (RSW) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from Cc Pwky @ Vincennes St to Knoxville Station Hall of Fame via Fort Myers Bus Stop, Orlando Bus Station, New York, NY, Knoxville, TN, Walmart, and Charlie Haun WB Aft Washington PK in around 46h 30m.

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