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How to get fromCape Coral to Santeeby plane, car, bus (Flixbus), bus, train, or taxi

Find Transport to Santee

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There are 9 ways to get from Cape Coral to Santee by plane, car, bus (Flixbus), bus, train, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Ft. Myers to Charleston International Airport, drive

    best
    1. Fly from Ft. Myers (RSW) to Charleston International Airport (CHS)plane plane RSW - CHS
    2. Drive from Charleston-Airport-CHS to Santeecar car
    5h 30m
    $114–521

  2. Drive 539.3 mi

    cheapest
    1. Drive from Cape Coral to Santeecar car 539.3 mi
    9h 34m
    $99–143

  3. Bus (Flixbus)

    1. Take the bus from Fort Myers Bus Stop to Orlando Bus Stationbus bus FlixBus 2421
    2. Take the bus from Orlando Bus Station to Orangeburgbus bus FlixBus 2433
    15h 53m
    $176–273

  4. Bus, train, drive

    1. Take the bus from Fort Myers Bus Stop to Hollywood Sheridan Trirail Stationbus bus
    2. Take the train from Fort Lauderdale Amtrak Station to Charleston Amtrak Stationtrain train
    3. Drive from Charleston Amtrak Station to Santeecar car
    20h 3m
    $236–484

  5. Fly Ft. Myers to Columbia, drive

    1. Fly from Ft. Myers (RSW) to Columbia (CAE)plane plane RSW - CAE
    2. Drive from Columbia-Airport-CAE to Santeecar car
    7h 35m
    $234–1,221

  6. Bus to Fort Lauderdale–Hollywood International Airport, fly to Charleston International Airport, drive

    1. Take the bus from Fort Myers Bus Stop to Fort Lauderdale International Airportbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Charleston International Airport (CHS)plane plane FLL - CHS
    3. Drive from Charleston-Airport-CHS to Santeecar car
    7h 55m
    $202–1,154

  7. Bus to Miami International Airport, fly to Charleston International Airport, drive

    1. Take the bus from Fort Myers Bus Stop to Miami Airport Stationbus bus
    2. Fly from Miami International Airport (MIA) to Charleston International Airport (CHS)plane plane MIA - CHS
    3. Drive from Charleston-Airport-CHS to Santeecar car
    8h 52m
    $536–1,064

  8. Bus to Tampa, fly to Charleston International Airport, drive

    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Charleston International Airport (CHS)plane plane TPA - CHS
    3. Drive from Charleston-Airport-CHS to Santeecar car
    9h 51m
    $174–402

  9. Bus, taxi

    1. Take the bus from Fort Myers Bus Stop to Orlando Bus Stationbus bus
    2. Take the bus from Orlando Bus Station to Jacksonvillebus bus
    3. Take the bus from Jacksonville to Walterboro, SCbus bus
    4. Take the taxi from Walterboro, SC to Santeetaxi taxi
    16h 5m
    $188–288

Ft. Myers (RSW) to Charleston International Airport (CHS) flights

Calendar11Weekly Planes
Duration2h 20mAverage Duration
Ticket$100Cheapest Price
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Questions & Answers

Map of how to get from Cape Coral to Santee.ExpandLaunch map view
  • Distance: 527.1 mi
  • Duration: 5h 30m

What companies run services between Cape Coral, FL, USA and Santee, SC, USA?

You can take a bus from Cc Pwky @ Vincennes St to Santee via Fort Myers Bus Stop, Orlando Bus Station, and Orangeburg in around 15h 53m.

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