Rome2Rio

How to get fromCape Girardeau to Buffaloby taxi, plane, train, bus (Greyhound), car, or bus

Find Transport to Buffalo

See all options

There are 10 ways to get from Cape Girardeau to Buffalo by taxi, plane, train, bus (Greyhound), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi to Barkley Regional Airport, fly

    best
    1. Take the taxi from Cape Girardeau to Barkley Regional Airport (PAH)taxi taxi
    2. Fly from Barkley Regional Airport (PAH) to Buffalo Niagara International Airport (BUF)plane plane PAH - BUF
    9h 44m
    $258–797

  2. Bus via Indianapolis

    cheapest
    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis to Toledobus bus
    4. Take the bus from Toledo to Clevelandbus bus
    5. Take the bus from Cleveland to Buffalobus bus
    19h 29m
    $110–272

  3. Taxi, train

    1. Take the taxi from Cape Girardeau to Carbondaletaxi taxi
    2. Take the train from Carbondale to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train
    19h 14m
    $330–852

  4. Drive  786 mi

    1. Drive from Cape Girardeau to Buffalocar car 786 mi
    13h 49m
    $144–208

  5. Taxi to Williamson County Regional Airport, fly

    1. Take the taxi from Cape Girardeau to Williamson County Regional Airport (MWA)taxi taxi
    2. Fly from Williamson County Regional Airport (MWA) to Buffalo Niagara International Airport (BUF)plane plane MWA - BUF
    7h 46m
    $268–885

  6. Bus to Lambert–St. Louis International Airport, fly

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Buffalo Niagara International Airport (BUF)plane plane STL - BUF
    8h 17m
    $143–718

  7. Fly from Cape Girardeau Municipal Airport

    1. Fly from Cape Girardeau Municipal Airport (CGI) to Buffalo Niagara International Airport (BUF)plane plane CGI - BUF
    7h 30m
    $139–656

  8. Taxi, bus to Nashville, fly

    1. Take the taxi from Cape Girardeau to Carbondale Intermodal Stationtaxi taxi
    2. Take the bus from Carbondale Intermodal Station to Nashville Bus Stationbus bus
    3. Fly from Nashville (BNA) to Buffalo Niagara International Airport (BUF)plane plane BNA - BUF
    9h 39m
    $250–902

  9. Bus, train

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Take the train from St. Louis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train
    20h 33m
    $242–747

  10. Bus

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Pittsburgh Intermodal Stationbus bus
    3. Take the bus from Pittsburgh, Pa to Buffalo, Nybus bus 510
    26h 24m
    $165–387

Barkley Regional Airport (PAH) to Buffalo Niagara International Airport (BUF) flights

Calendar22Weekly Planes
Duration9h 55mAverage Duration
Ticket$114Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Cape Girardeau to Buffalo.ExpandLaunch map view
  • Distance: 739.6 mi
  • Duration: 9h 44m

What companies run services between Cape Girardeau, MO, USA and Buffalo, NY, USA?

You can take a vehicle from Cape Girardeau to Buffalo via Cape Girardeau, St Louis Bus Station, Indianapolis, Toledo, and Cleveland in around 19h 29m. Alternatively, Corporate Flight Management Inc, United Airlines, and two other airlines fly from Cape Girardeau Municipal Airport (CGI) to Buffalo Niagara International Airport (BUF) 3 times a day.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There