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How to get fromCape Girardeau to Buffaloby taxi, plane, train, bus (Greyhound), car, or bus

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There are 9 ways to get from Cape Girardeau to Buffalo by taxi, plane, train, bus (Greyhound), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi to Williamson County Regional Airport, fly

    best
    1. Take the taxi from Cape Girardeau to Williamson County Regional Airport (MWA)taxi taxi
    2. Fly from Williamson County Regional Airport (MWA) to Buffalo Niagara International Airport (BUF)plane plane MWA - BUF
    7h 24m
    $284–936

  2. Drive 786 mi

    cheapest
    1. Drive from Cape Girardeau to Buffalocar car 786 mi
    13h 49m
    $144–208

  3. Taxi, train

    1. Take the taxi from Cape Girardeau to Carbondaletaxi taxi
    2. Take the train from Carbondale to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train
    19h 14m
    $375–822

  4. Bus via Reading

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Cincinnati Bus Stationbus bus
    4. Take the bus from Cincinnati, OH to Buffalo, NYbus bus
    20h 34m

  5. Taxi to Barkley Regional Airport, fly

    1. Take the taxi from Cape Girardeau to Barkley Regional Airport (PAH)taxi taxi
    2. Fly from Barkley Regional Airport (PAH) to Buffalo Niagara International Airport (BUF)plane plane PAH - BUF
    9h 38m
    $284–898

  6. Bus to Lambert–St. Louis International Airport, fly

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Buffalo Niagara International Airport (BUF)plane plane STL - BUF
    7h 55m
    $189–925

  7. Fly from Cape Girardeau Municipal Airport

    1. Fly from Cape Girardeau Municipal Airport (CGI) to Buffalo Niagara International Airport (BUF)plane plane CGI - BUF
    7h 11m
    $155–757

  8. Bus, train

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Take the train from St. Louis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train
    20h 33m
    $287–723

  9. Bus

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Pittsburgh Intermodal Stationbus bus
    3. Take the bus from Pittsburgh, Pa to Buffalo, Nybus bus 510
    24h 39m
    $165–423

Williamson County Regional Airport (MWA) to Buffalo Niagara International Airport (BUF) flights

Calendar26Weekly Planes
Duration6h 35mAverage Duration
Ticket$153Cheapest Price
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Questions & Answers

Map of how to get from Cape Girardeau to Buffalo.ExpandLaunch map view
  • Distance: 720.2 mi
  • Duration: 7h 24m

What companies run services between Cape Girardeau, MO, USA and Buffalo, NY, USA?

You can take a vehicle from Cape Girardeau to Buffalo, NY via Cape Girardeau, St Louis Bus Station, Indianapolis Union Station, Cincinnati Bus Station, and Cincinnati, OH in around 20h 34m. Alternatively, Corporate Flight Management Inc, United Airlines, and two other airlines fly from Cape Girardeau Municipal Airport (CGI) to Buffalo Niagara International Airport (BUF) twice daily.

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