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How to get fromCape Girardeau to Chicagoby taxi, plane, train, bus, car, or bus (Greyhound, Flixbus)

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There are 9 ways to get from Cape Girardeau to Chicago by taxi, plane, train, bus, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi to Williamson County Regional Airport, fly to Chicago O'Hare International Airport

    best
    1. Take the taxi from Cape Girardeau to Williamson County Regional Airport (MWA)taxi taxi
    2. Fly from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD)plane plane MWA - ORD
    3h 41m
    $215–382

  2. Drive  371.9 mi

    cheapest
    1. Drive from Cape Girardeau to Chicagocar car 371.9 mi
    6h 18m
    $68–98

  3. Taxi, train

    1. Take the taxi from Cape Girardeau to Carbondaletaxi taxi
    2. Take the train from Carbondale to Chicago Union Stationtrain train Saluki / ...
    6h 30m
    $178–302

  4. Taxi, bus

    1. Take the taxi from Cape Girardeau to Anna - Shelltaxi taxi
    2. Take the bus from Anna - Shell to Chicagobus bus Querétaro
    8h
    $147–184

  5. Taxi to Barkley Regional Airport, fly to Chicago O'Hare International Airport

    1. Take the taxi from Cape Girardeau to Barkley Regional Airport (PAH)taxi taxi
    2. Fly from Barkley Regional Airport (PAH) to Chicago O'Hare International Airport (ORD)plane plane PAH - ORD
    3h 53m
    $185–434

  6. Bus to Lambert–St. Louis International Airport, fly to Chicago Midway International Airport

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW)plane plane STL - MDW
    5h 24m
    $79–394

  7. Bus to Lambert–St. Louis International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Chicago O'Hare International Airport (ORD)plane plane STL - ORD
    5h 46m
    $349–744

  8. Bus, train

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus Greyhound US1173
    2. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    7h 49m
    $94–196

  9. Bus

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus Greyhound US1173
    2. Take the bus from St Louis Bus Station to Chicago Bus Stationbus bus FlixBus N2521 / ...
    8h 59m
    $69–111

Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD) flights

Calendar14Weekly Planes
Duration1h 44mAverage Duration
Ticket$46Cheapest Price
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Comparing Your Travel Options

Map of how to get from Cape Girardeau to Chicago.ExpandLaunch map view
  • Distance: 373.6 mi
  • Duration: 3h 41m

What companies run services between Cape Girardeau, MO, USA and Chicago, IL, USA?

You can take a vehicle from Cape Girardeau to Chicago Bus Station via Cape Girardeau and St Louis Bus Station in around 8h 59m.

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