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How to get fromCape Girardeau to Des Moinesby bus (Greyhound), car, taxi, plane, or bus

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There are 7 ways to get from Cape Girardeau to Des Moines by bus (Greyhound), car, taxi, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus Greyhound US1173
    2. Take the bus from St Louis Bus Station to Des Moinesbus bus Greyhound US0153S
    11h 24m
    $84–173

  2. Drive 430.4 mi

    cheapest
    1. Drive from Cape Girardeau to Des Moinescar car 430.4 mi
    8h 16m
    $79–114

  3. Taxi to Barkley Regional Airport, fly

    1. Take the taxi from Cape Girardeau to Barkley Regional Airport (PAH)taxi taxi
    2. Fly from Barkley Regional Airport (PAH) to Des Moines (DSM)plane plane PAH - DSM
    7h 7m
    $270–790

  4. Bus via Iowa City

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Take the bus from Saint Louis to Iowa Citybus bus
    3. Take the bus from Iowa City to Des Moinesbus bus
    12h 44m

  5. Taxi to Williamson County Regional Airport, fly

    1. Take the taxi from Cape Girardeau to Williamson County Regional Airport (MWA)taxi taxi
    2. Fly from Williamson County Regional Airport (MWA) to Des Moines (DSM)plane plane MWA - DSM
    6h 1m
    $270–878

  6. Bus to Lambert–St. Louis International Airport, fly

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Des Moines (DSM)plane plane STL - DSM
    7h 9m
    $184–817

  7. Fly from Cape Girardeau Municipal Airport

    1. Fly from Cape Girardeau Municipal Airport (CGI) to Des Moines (DSM)plane plane CGI - DSM
    4h 50m
    $211–849

Barkley Regional Airport (PAH) to Des Moines (DSM) flights

Calendar28Weekly Planes
Duration7h 36mAverage Duration
Ticket$117Cheapest Price
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Questions & Answers

Map of how to get from Cape Girardeau to Des Moines.ExpandLaunch map view
  • Distance: 532 mi
  • Duration: 11h 24m

What companies run services between Cape Girardeau, MO, USA and Des Moines, IA, USA?

You can take a vehicle from Cape Girardeau to Des Moines via Cape Girardeau and St Louis Bus Station in around 11h 24m. Alternatively, Corporate Flight Management Inc, United Airlines, and two other airlines fly from Cape Girardeau Municipal Airport (CGI) to Des Moines (DSM) 5 times a day.

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Bus operators
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