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How to get fromCape Girardeau to Destinby bus, plane, train, taxi, or car

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There are 8 ways to get from Cape Girardeau to Destin by bus, plane, train, taxi, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Lambert–St. Louis International Airport, fly to Destin–Fort Walton Beach Airport

    best
    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Destin–Fort Walton Beach Airport (VPS)plane plane STL - VPS
    5h 49m
    $143–525

  2. Drive  607.8 mi

    cheapest
    1. Drive from Cape Girardeau to Destincar car 607.8 mi
    11h 54m
    $111–161

  3. Bus, train, taxi

    1. Take the bus from Cape Girardeau to New Orleans Bus Stationbus bus
    2. Take the train from New Orleans Union Passenger Terminal to Gulfport Amtrak Statrain train
    3. Take the bus from Gulfport to Crestviewbus bus
    4. Take the taxi from Crestview to Destintaxi taxi
    21h 22m
    $255–383

  4. Taxi, train, bus

    1. Take the taxi from Cape Girardeau to Carbondaletaxi taxi
    2. Take the train from Carbondale to New Orleans Union Passenger Terminaltrain train
    3. Take the train from New Orleans Union Passenger Terminal to Pascagoulatrain train
    4. Take the bus from Pascagoula to Crestviewbus bus
    5. Take the taxi from Crestview to Destintaxi taxi
    22h 4m
    $429–802

  5. Bus to Lambert–St. Louis International Airport, fly to Northwest Florida Beaches International Airport, taxi

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP)plane plane STL - ECP
    3. Take the taxi from Northwest Florida Beaches International Airport (ECP) to Destintaxi taxi
    6h 32m
    $243–660

  6. Bus to Midamerica St. Louis Airport, fly to Destin–Fort Walton Beach Airport

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Midamerica St. Louis Airport (BLV) to Destin–Fort Walton Beach Airport (VPS)plane plane BLV - VPS
    6h 8m
    $156–503

  7. Bus to Lambert–St. Louis International Airport, fly to Pensacola International Airport, taxi

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Pensacola International Airport (PNS)plane plane STL - PNS
    3. Take the taxi from Pensacola-Airport-PNS to Destintaxi taxi
    6h 36m
    $203–510

  8. Taxi, bus to Nashville, fly to Destin–Fort Walton Beach Airport

    1. Take the taxi from Cape Girardeau to Carbondale Intermodal Stationtaxi taxi
    2. Take the bus from Carbondale Intermodal Station to Nashville Bus Stationbus bus
    3. Fly from Nashville (BNA) to Destin–Fort Walton Beach Airport (VPS)plane plane BNA - VPS
    8h 25m
    $240–629

Lambert–St. Louis International Airport (STL) to Destin–Fort Walton Beach Airport (VPS) flights

Calendar45Weekly Planes
Duration3h 28mAverage Duration
Ticket$76Cheapest Price
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Comparing Your Travel Options

Map of how to get from Cape Girardeau to Destin.ExpandLaunch map view
  • Distance: 755.4 mi
  • Duration: 5h 49m

What companies run services between Cape Girardeau, MO, USA and Destin, FL, USA?

There is no direct connection from Cape Girardeau to Destin. However, you can take the taxi to Cape Girardeau, take the bus to St Louis Bus Station, walk to CIVIC CENTER station, take the train to LAMBERT AIRPORT TERMINAL #1 station, walk to Lambert–St. Louis International Airport (STL) airport, fly to Destin–Fort Walton Beach Airport (VPS), then take the taxi to Destin. Alternatively, you can take the taxi to Cape Girardeau, take the bus to New Orleans Bus Station, walk to New Orleans Union Passenger Terminal, take the train to Gulfport Amtrak Sta, walk to Gulfport, take the bus to Crestview, then take the taxi to Destin.

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