Rome2Rio

How to get fromCape Girardeau to Destinby bus, plane, train, taxi, or car

Find Transport to Destin

See all options

There are 9 ways to get from Cape Girardeau to Destin by bus, plane, train, taxi, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Lambert–St. Louis International Airport, fly to Destin–Fort Walton Beach Airport

    best
    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Destin–Fort Walton Beach Airport (VPS)plane plane STL - VPS
    5h 49m
    $158–581

  2. Drive 607.8 mi

    cheapest
    1. Drive from Cape Girardeau to Destincar car 607.8 mi
    11h 54m
    $111–161

  3. Bus, train, taxi

    1. Take the bus from Cape Girardeau to New Orleans Bus Stationbus bus
    2. Take the train from New Orleans Union Passenger Terminal to Gulfport Amtrak Statrain train
    3. Take the bus from Gulfport to Crestviewbus bus
    4. Take the taxi from Crestview to Destintaxi taxi
    21h 22m
    $253–408

  4. Taxi, train, bus

    1. Take the taxi from Cape Girardeau to Carbondaletaxi taxi
    2. Take the train from Carbondale to New Orleans Union Passenger Terminaltrain train
    3. Take the train from New Orleans Union Passenger Terminal to Mobile Amtrak Statrain train
    4. Take the bus from Mobile to Crestviewbus bus
    5. Take the taxi from Crestview to Destintaxi taxi
    22h 16m
    $458–787

  5. Fly Cape Girardeau Municipal Airport to Pensacola International Airport, taxi

    1. Fly from Cape Girardeau Municipal Airport (CGI) to Pensacola International Airport (PNS)plane plane CGI - PNS
    2. Take the taxi from Pensacola-Airport-PNS to Destintaxi taxi
    3h 16m
    $264–668

  6. Bus to Midamerica St. Louis Airport, fly to Destin–Fort Walton Beach Airport

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Midamerica St. Louis Airport (BLV) to Destin–Fort Walton Beach Airport (VPS)plane plane BLV - VPS
    6h 10m
    $156–489

  7. Bus to Lambert–St. Louis International Airport, fly to Northwest Florida Beaches International Airport, taxi

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP)plane plane STL - ECP
    3. Take the taxi from Northwest Florida Beaches International Airport (ECP) to Destintaxi taxi
    6h 32m
    $258–706

  8. Bus to Lambert–St. Louis International Airport, fly to Pensacola International Airport, taxi

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Pensacola International Airport (PNS)plane plane STL - PNS
    3. Take the taxi from Pensacola-Airport-PNS to Destintaxi taxi
    6h 41m
    $228–636

  9. Taxi, bus to Nashville, fly to Destin–Fort Walton Beach Airport

    1. Take the taxi from Cape Girardeau to Carbondale Intermodal Stationtaxi taxi
    2. Take the bus from Carbondale Intermodal Station to Nashville Bus Stationbus bus
    3. Fly from Nashville (BNA) to Destin–Fort Walton Beach Airport (VPS)plane plane BNA - VPS
    8h 15m
    $235–614

Lambert–St. Louis International Airport (STL) to Destin–Fort Walton Beach Airport (VPS) flights

Calendar25Weekly Planes
Duration3h 14mAverage Duration
Ticket$91Cheapest Price
See schedules

Questions & Answers

Map of how to get from Cape Girardeau to Destin.ExpandLaunch map view
  • Distance: 755.4 mi
  • Duration: 5h 49m

What companies run services between Cape Girardeau, MO, USA and Destin, FL, USA?

There is no direct connection from Cape Girardeau to Destin. However, you can take the taxi to Cape Girardeau, take the bus to St Louis Bus Station, walk to CIVIC CENTER station, take the train to LAMBERT AIRPORT TERMINAL #1 station, walk to Lambert–St. Louis International Airport (STL) airport, fly to Destin–Fort Walton Beach Airport (VPS), then take the taxi to Destin. Alternatively, you can take the taxi to Cape Girardeau, take the bus to New Orleans Bus Station, walk to New Orleans Union Passenger Terminal, take the train to Gulfport Amtrak Sta, walk to Gulfport, take the bus to Crestview, then take the taxi to Destin.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound