Rome2Rio

How to get fromCape Girardeau to Floridaby bus, plane, taxi, car, or bus (Greyhound, Flixbus)

Find Transport to Florida

See all options

There are 10 ways to get from Cape Girardeau to Florida by bus, plane, taxi, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Lambert–St. Louis International Airport, fly to Jacksonville

    best
    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Jacksonville (JAX)plane plane STL - JAX
    7h 10m
    $128–592

  2. Taxi, bus

    1. Take the taxi from Cape Girardeau to Carbondale Intermodal Stationtaxi taxi
    2. Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Jacksonvillebus bus
    16h 40m
    $223–327

  3. Drive  754.8 mi

    1. Drive from Cape Girardeau to Jacksonvillecar car 754.8 mi
    13h 54m
    $138–199

  4. Bus to Lambert–St. Louis International Airport, fly to Tampa

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Tampa (TPA)plane plane STL - TPA
    7h
    $579–2,041

  5. Bus to Lambert–St. Louis International Airport, fly to Orlando

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Orlando (MCO)plane plane STL - MCO
    7h 23m
    $211–364

  6. Bus to Lambert–St. Louis International Airport, fly to Ft. Myers

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Ft. Myers (RSW)plane plane STL - RSW
    8h 26m
    $150–694

  7. Bus to Midamerica St. Louis Airport, fly to Orlando Sanford

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Midamerica St. Louis Airport (BLV) to Orlando Sanford (SFB)plane plane BLV - SFB
    6h 41m
    $190–572

  8. Taxi, bus to Nashville, fly to Jacksonville

    1. Take the taxi from Cape Girardeau to Carbondale Intermodal Stationtaxi taxi
    2. Take the bus from Carbondale Intermodal Station to Nashville Bus Stationbus bus
    3. Fly from Nashville (BNA) to Jacksonville (JAX)plane plane BNA - JAX
    9h 42m
    $216–657

  9. Bus to Midamerica St. Louis Airport, fly to Saint Petersburg–Clearwater International Airport

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Midamerica St. Louis Airport (BLV) to Saint Petersburg–Clearwater International Airport (PIE)plane plane BLV - PIE
    8h 2m
    $136–503

  10. Bus

    1. Take the bus from Cape Girardeau to Memphis Bus Stationbus bus
    2. Take the bus from Memphis Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Jacksonvillebus bus
    19h 49m
    $146–246

Lambert–St. Louis International Airport (STL) to Jacksonville (JAX) flights

Calendar73Weekly Planes
Duration3h 48mAverage Duration
Ticket$102Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Cape Girardeau to Florida.ExpandLaunch map view
  • Distance: 900.9 mi
  • Duration: 7h 10m

What companies run services between Cape Girardeau, MO, USA and Florida, USA?

You can take a vehicle from Cape Girardeau to Newnan St + Ashley St via Cape Girardeau, Memphis Bus Station, Atlanta Bus Station, Jacksonville, and JRTC Bay J in around 19h 49m.

Airlines
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There