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How to get fromCape Girardeau to Great Smoky Mountainsby taxi, plane, car, bus, or train

Find Transport to Great Smoky Mountains

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There are 9 ways to get from Cape Girardeau to Great Smoky Mountains by taxi, plane, car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi to Williamson County Regional Airport, fly, drive

    best
    1. Take the taxi from Cape Girardeau to Williamson County Regional Airport (MWA)taxi taxi
    2. Fly from Williamson County Regional Airport (MWA) to Mcghee Tyson Airport (TYS)plane plane MWA - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    7h 55m
    $323–1,123

  2. Drive 433.1 mi

    cheapest
    1. Drive from Cape Girardeau to Great Smoky Mountainscar car 433.1 mi
    8h 31m
    $79–115

  3. Taxi, bus, drive

    1. Take the taxi from Cape Girardeau to Carbondale Intermodal Stationtaxi taxi
    2. Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Winston Salem(Trans Center)bus bus
    4. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    5. Drive from Asheville, NC to Great Smoky Mountainscar car
    21h 59m
    $252–402

  4. Taxi to Barkley Regional Airport, fly, drive

    1. Take the taxi from Cape Girardeau to Barkley Regional Airport (PAH)taxi taxi
    2. Fly from Barkley Regional Airport (PAH) to Mcghee Tyson Airport (TYS)plane plane PAH - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    10h 1m
    $313–1,035

  5. Bus to Lambert–St. Louis International Airport, fly, drive

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS)plane plane STL - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    9h 28m
    $167–912

  6. Fly from Cape Girardeau Municipal Airport, drive

    1. Fly from Cape Girardeau Municipal Airport (CGI) to Mcghee Tyson Airport (TYS)plane plane CGI - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    7h 27m
    $194–894

  7. Taxi, bus to Nashville, fly, drive

    1. Take the taxi from Cape Girardeau to Carbondale Intermodal Stationtaxi taxi
    2. Take the bus from Carbondale Intermodal Station to Nashville Bus Stationbus bus
    3. Fly from Nashville (BNA) to Mcghee Tyson Airport (TYS)plane plane BNA - TYS
    4. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    9h 21m
    $230–845

  8. Bus, drive (Greyhound)

    1. Take the bus from Cape Girardeau to Memphis Bus Stationbus bus
    2. Take the bus from Memphis Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Winston Salem(Trans Center)bus bus
    4. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    5. Drive from Asheville, NC to Great Smoky Mountainscar car
    24h 48m
    $167–333

  9. Bus, train, drive

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus
    3. Take the train from Indianapolis to Ashland Amtrak Stationtrain train
    4. Take the bus from Ashland Bus Station to Winston Salem(Trans Center)bus bus
    5. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    6. Drive from Asheville, NC to Great Smoky Mountainscar car
    28h 28m
    $218–443

Williamson County Regional Airport (MWA) to Mcghee Tyson Airport (TYS) flights

Calendar33Weekly Planes
Duration7h 35mAverage Duration
Ticket$183Cheapest Price
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Questions & Answers

Map of how to get from Cape Girardeau to Great Smoky Mountains.ExpandLaunch map view
  • Distance: 425.3 mi
  • Duration: 7h 55m

What companies run services between Cape Girardeau, MO, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Cape Girardeau to Great Smoky Mountains. However, you can take the taxi to Williamson County Regional Airport (MWA) airport, fly to Mcghee Tyson Airport (TYS), then drive to Great Smoky Mountains. Alternatively, you can take the taxi to Carbondale Intermodal Station, take the bus to Atlanta Bus Station, take the bus to Winston Salem(Trans Center), take the bus to Asheville, NC, then drive to Great Smoky Mountains.

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