There are 3 ways to get from Cape Girardeau to Kentucky by bus (Greyhound), car, taxi, train, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Cape Girardeau to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Evansville Bus Stationbus
- Take the bus from Evansville, IN to Louisville, KYbus
9h 34m$93–223Drive 255.5 mi
cheapest- Drive from Cape Girardeau to Louisvillecar 255.5 mi
4h 51m$44–64Taxi, train, bus
- Take the taxi from Cape Girardeau to Carbondaletaxi
- Take the train from Carbondale to Champaign-Urbanatrain
- Take the bus from Champaign Intermodal Trans Ctr to Indianapolis Union Stationbus
- Take the bus from Indianapolis Union Station to Louisville, KYbus
9h 45m$247–362
Comparing Your Travel Options
The cheapest way to get from Cape Girardeau to Kentucky is to drive which costs $40 - $65 and takes 4h 51m.
The fastest way to get from Cape Girardeau to Kentucky is to drive which takes 4h 51m and costs $40 - $65.
No, there is no direct bus from Cape Girardeau to Kentucky. However, there are services departing from Cape Girardeau and arriving at Louisville, KY via St Louis Bus Station and Evansville, IN. The journey, including transfers, takes approximately 9h 34m.
The distance between Cape Girardeau and Kentucky is 402 miles. The road distance is 257 miles.
The best way to get from Cape Girardeau to Kentucky without a car is to bus which takes 9h 34m and costs $90 - $230.
It takes approximately 9h 34m to get from Cape Girardeau to Kentucky, including transfers.
Cape Girardeau to Kentucky bus services, operated by Greyhound USA, depart from Cape Girardeau station.
Cape Girardeau to Kentucky bus services, operated by Greyhound USA, arrive at St Louis Bus Station.
Kentucky is 1h ahead of Cape Girardeau. It is currently 2:09 PM in Cape Girardeau and 3:09 PM in Kentucky.
Yes, the driving distance between Cape Girardeau to Kentucky is 257 miles. It takes approximately 4h 51m to drive from Cape Girardeau to Kentucky.
What companies run services between Cape Girardeau, MO, USA and Kentucky, USA?
You can take a vehicle from Cape Girardeau to Louisville, KY via Cape Girardeau, St Louis Bus Station, and Evansville, IN in around 9h 34m.
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Carbondale to Champaign-Urbana
- Ave. Duration
- 2h 50m
- Frequency
- 3 times a day
- Estimated price
- $100–160
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Cape Girardeau to St Louis Bus Station
- Ave. Duration
- 1h 50m
- Frequency
- Twice daily
- Estimated price
- $21–35
- Website
- Greyhound
Bus from St Louis Bus Station to Evansville Bus Station
- Ave. Duration
- 3h 25m
- Frequency
- 4 times a day
- Estimated price
- $30–50
- Website
- Greyhound
Bus from Champaign Intermodal Trans Ctr to Indianapolis Union Station
- Ave. Duration
- 2h
- Frequency
- Twice daily
- Estimated price
- $22–35
- Website
- Greyhound
- Phone
- +1 502-368-5644 x 135
- Website
- Miller Transportation
Bus from Evansville, IN to Louisville, KY
- Ave. Duration
- 2h 15m
- Frequency
- Once daily
- Estimated price
- $35–130
- Website
- Miller Transportation
Rome2Rio's guide to Amtrak Thruway
Contact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from Indianapolis Union Station to Louisville, KY
- Ave. Duration
- 1h 55m
- Frequency
- Twice daily
- Estimated price
- $22–45
- Website
- Amtrak
- Adult
- $22–45
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide
Booking & Getting There
There are 610+ hotels available in Kentucky.









