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How to get fromCape Girardeau to Knoxvilleby taxi, plane, bus (Greyhound), bus, train, or car

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There are 10 ways to get from Cape Girardeau to Knoxville by taxi, plane, bus (Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi to Williamson County Regional Airport, fly to Mcghee Tyson Airport

    best
    1. Take the taxi from Cape Girardeau to Williamson County Regional Airport (MWA)taxi taxi
    2. Fly from Williamson County Regional Airport (MWA) to Mcghee Tyson Airport (TYS)plane plane MWA - TYS
    6h 20m
    $348–1,077

  2. Drive 376.6 mi

    cheapest
    1. Drive from Cape Girardeau to Knoxvillecar car 376.6 mi
    6h 42m
    $69–100

  3. Bus

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    41h 21m
    $357–596

  4. Bus, train

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Take the train from St. Louis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York to Knoxvillebus bus Nyc
    42h 34m
    $597–1,136

  5. Taxi to Barkley Regional Airport, fly to Mcghee Tyson Airport

    1. Take the taxi from Cape Girardeau to Barkley Regional Airport (PAH)taxi taxi
    2. Fly from Barkley Regional Airport (PAH) to Mcghee Tyson Airport (TYS)plane plane PAH - TYS
    8h 26m
    $338–989

  6. Bus to Lambert–St. Louis International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS)plane plane STL - TYS
    7h 53m
    $202–866

  7. Fly Cape Girardeau Municipal Airport to Mcghee Tyson Airport

    1. Fly from Cape Girardeau Municipal Airport (CGI) to Mcghee Tyson Airport (TYS)plane plane CGI - TYS
    5h 52m
    $219–848

  8. Taxi, bus to Nashville, fly to Mcghee Tyson Airport

    1. Take the taxi from Cape Girardeau to Carbondale Intermodal Stationtaxi taxi
    2. Take the bus from Carbondale Intermodal Station to Nashville Bus Stationbus bus
    3. Fly from Nashville (BNA) to Mcghee Tyson Airport (TYS)plane plane BNA - TYS
    7h 46m
    $270–849

  9. Bus to Lambert–St. Louis International Airport, fly to Nashville, drive

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Nashville (BNA)plane plane STL - BNA
    3. Drive from Nashville-Airport-BNA to Knoxvillecar car
    7h 36m
    $137–696

  10. Bus, train via Ossining

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Take the train from St. Louis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    4. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    5. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    43h 4m
    $552–1,063

Williamson County Regional Airport (MWA) to Mcghee Tyson Airport (TYS) flights

Calendar33Weekly Planes
Duration7h 36mAverage Duration
Ticket$166Cheapest Price
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Questions & Answers

Map of how to get from Cape Girardeau to Knoxville.ExpandLaunch map view
  • Distance: 378.9 mi
  • Duration: 6h 20m

What companies run services between Cape Girardeau, MO, USA and Knoxville, TN, USA?

You can take a vehicle from Cape Girardeau to Knoxville via Cape Girardeau, St Louis Bus Station, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 41h 21m. Alternatively, Corporate Flight Management Inc, American Airlines, and two other airlines fly from Cape Girardeau Municipal Airport (CGI) to Mcghee Tyson Airport (TYS) twice daily.

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