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How to get fromCape Girardeau to Lafayetteby bus (Greyhound, Amtrak), taxi, train, car, plane, bus, or shuttle

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There are 10 ways to get from Cape Girardeau to Lafayette by bus (Greyhound, Amtrak), taxi, train, car, plane, bus, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Lafayette Amtrak Stationbus bus
    9h 39m
    $73–158

  2. Drive 316 mi

    cheapest
    1. Drive from Cape Girardeau to Lafayettecar car 316 mi
    6h 7m
    $58–84

  3. Taxi, train

    1. Take the taxi from Cape Girardeau to Carbondaletaxi taxi
    2. Take the train from Carbondale to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    10h 31m
    $233–412

  4. Fly Cape Girardeau Municipal Airport to Chicago O'Hare International Airport, train

    1. Fly from Cape Girardeau Municipal Airport (CGI) to Chicago O'Hare International Airport (ORD)plane plane CGI - ORD
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    6h 57m
    $156–333

  5. Bus, train

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Take the train from St. Louis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    11h 50m
    $144–313

  6. Taxi to Williamson County Regional Airport, fly to Chicago O'Hare International Airport, train

    1. Take the taxi from Cape Girardeau to Williamson County Regional Airport (MWA)taxi taxi
    2. Fly from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD)plane plane MWA - ORD
    3. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    7h 51m
    $250–452

  7. Fly Cape Girardeau Municipal Airport to Purdue University Airport

    1. Fly from Cape Girardeau Municipal Airport (CGI) to Purdue University Airport (LAF)plane plane CGI - LAF
    9h 30m
    $165–529

  8. Taxi to Barkley Regional Airport, fly to Chicago O'Hare International Airport, train

    1. Take the taxi from Cape Girardeau to Barkley Regional Airport (PAH)taxi taxi
    2. Fly from Barkley Regional Airport (PAH) to Chicago O'Hare International Airport (ORD)plane plane PAH - ORD
    3. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    7h 57m
    $220–514

  9. Taxi to Williamson County Regional Airport, fly to Purdue University Airport

    1. Take the taxi from Cape Girardeau to Williamson County Regional Airport (MWA)taxi taxi
    2. Fly from Williamson County Regional Airport (MWA) to Purdue University Airport (LAF)plane plane MWA - LAF
    6h 23m
    $199–558

  10. Taxi, bus to Nashville, fly to Indianapolis, shuttle

    1. Take the taxi from Cape Girardeau to Carbondale Intermodal Stationtaxi taxi
    2. Take the bus from Carbondale Intermodal Station to Nashville Bus Stationbus bus
    3. Fly from Nashville (BNA) to Indianapolis (IND)plane plane BNA - IND
    4. Take a shuttle bus from Indianapolis Airport to Holiday Inn City Centreshuttle bus
    9h 31m
    $459–1,314

Cape Girardeau Municipal Airport (CGI) to Chicago O'Hare International Airport (ORD) flights

Calendar7Weekly Planes
Duration1h 45mAverage Duration
Ticket$99Cheapest Price
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Questions & Answers

Map of how to get from Cape Girardeau to Lafayette.ExpandLaunch map view
  • Distance: 421.9 mi
  • Duration: 9h 39m

What companies run services between Cape Girardeau, MO, USA and Lafayette, IN, USA?

You can take a vehicle from Cape Girardeau to Lafayette Amtrak Station via Cape Girardeau, St Louis Bus Station, and Indianapolis Union Station in around 9h 39m. Alternatively, Corporate Flight Management Inc and United Airlines fly from Cape Girardeau Municipal Airport (CGI) to Purdue University Airport (LAF) once daily.

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