There are 6 ways to get from Cape Girardeau to Lexington by taxi, plane, bus, car, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Taxi to Williamson County Regional Airport, fly
best- Take the taxi from Cape Girardeau to Williamson County Regional Airport (MWA)taxi
- Fly from Williamson County Regional Airport (MWA) to Columbia (CAE)plane MWA - CAE
6h 20m$431–1,492Drive 634.7 mi
cheapest- Drive from Cape Girardeau to Lexingtoncar 634.7 mi
11h 14m$116–168Taxi, bus
- Take the taxi from Cape Girardeau to Carbondale Intermodal Stationtaxi
- Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to Camdenbus
- Take the bus from Camden to Columbia, SCbus Nyc
17h$266–397Bus to Lambert–St. Louis International Airport, fly
- Take the bus from Cape Girardeau to St Louis Bus Stationbus
- Fly from Lambert–St. Louis International Airport (STL) to Columbia (CAE)plane STL - CAE
7h 41m$285–1,381Fly from Cape Girardeau Municipal Airport
- Fly from Cape Girardeau Municipal Airport (CGI) to Columbia (CAE)plane CGI - CAE
6h 11m$292–1,263Bus
- Take the bus from Cape Girardeau to Memphis Bus Stationbus
- Take the bus from Memphis Bus Station to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to Camdenbus
- Take the bus from Camden to Columbia, SCbus Nyc
19h 49m$182–328
Williamson County Regional Airport (MWA) to Columbia (CAE) flights
Questions & Answers
The cheapest way to get from Cape Girardeau to Lexington is to drive which costs $110 - $170 and takes 11h 14m.
The fastest way to get from Cape Girardeau to Lexington is to fly which takes 6h 11m and costs $290 - $1,300.
No, there is no direct bus from Cape Girardeau to Lexington. However, there are services departing from Cape Girardeau and arriving at Columbia, SC via Memphis Bus Station, Atlanta Bus Station and Camden. The journey, including transfers, takes approximately 19h 49m.
The distance between Cape Girardeau and Lexington is 583 miles. The road distance is 638.4 miles.
The best way to get from Cape Girardeau to Lexington without a car is to taxi and bus which takes 17h and costs $260 - $400.
It takes approximately 6h 20m to get from Cape Girardeau to Lexington, including transfers.
Cape Girardeau to Lexington bus services, operated by Greyhound USA, depart from Cape Girardeau station.
The best way to get from Cape Girardeau to Lexington is to fly which takes 6h 11m and costs $290 - $1,300. Alternatively, you can bus, which costs $180 - $330 and takes 19h 49m.
Cape Girardeau to Lexington bus services, operated by Greyhound USA, arrive at Memphis Bus Station.
Lexington is 1h ahead of Cape Girardeau. It is currently 8:40 PM in Cape Girardeau and 9:40 PM in Lexington.
What companies run services between Cape Girardeau, MO, USA and Lexington, SC, USA?
Corporate Flight Management Inc, American Airlines, and Delta fly from Cape Girardeau Municipal Airport (CGI) to Columbia (CAE) twice daily. Alternatively, you can take a vehicle from Cape Girardeau to Lexington via Cape Girardeau, Memphis Bus Station, Atlanta Bus Station, Camden, and Columbia, SC in around 19h 49m.
- Website
- aa.com
Flights from Williamson County Regional Airport to Columbia via Chicago O'Hare
- Ave. Duration
- 6h 5m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $270–1,300
Flights from Williamson County Regional Airport to Columbia via Chicago O'Hare, Charlotte
- Ave. Duration
- 8h 26m
- When
- Every day
- Estimated price
- $280–1,400
Flights from Lambert–St. Louis International Airport to Columbia via Charlotte
- Ave. Duration
- 4h 30m
- When
- Every day
- Estimated price
- $230–1,300
Flights from Lambert–St. Louis International Airport to Columbia via Philadelphia
- Ave. Duration
- 5h 17m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $380–1,700
Flights from Lambert–St. Louis International Airport to Columbia via Dallas/Ft.Worth
- Ave. Duration
- 5h 49m
- When
- Every day
- Estimated price
- $410–1,800
Flights from Lambert–St. Louis International Airport to Columbia via Chicago O'Hare
- Ave. Duration
- 6h 2m
- When
- Every day
- Estimated price
- $290–1,400
Flights from Lambert–St. Louis International Airport to Columbia via New York La Guardia
- Ave. Duration
- 7h 47m
- When
- Every day
- Estimated price
- $420–1,800
Flights from Cape Girardeau Municipal Airport to Columbia via Chicago O'Hare
- Ave. Duration
- 5h 45m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $240–1,200
Flights from Cape Girardeau Municipal Airport to Columbia via Dallas/Ft.Worth
- Ave. Duration
- 5h 57m
- When
- Monday, Tuesday, Thursday, Friday, and Sunday
- Estimated price
- $310–1,400
Flights from Cape Girardeau Municipal Airport to Columbia via Pensacola, Charlotte
- Ave. Duration
- 9h 32m
- When
- Wednesday
- Estimated price
- $250–1,200
- Website
- delta.com
Flights from Lambert–St. Louis International Airport to Columbia via Atlanta
- Ave. Duration
- 4h 59m
- When
- Every day
- Estimated price
- $240–1,300
Flights from Lambert–St. Louis International Airport to Columbia via New York La Guardia
- Ave. Duration
- 7h 17m
- When
- Saturday
- Estimated price
- $420–1,800
Flights from Cape Girardeau Municipal Airport to Columbia via Pensacola, Atlanta
- Ave. Duration
- 7h 8m
- When
- Saturday
- Estimated price
- $600–2,300
- Website
- united.com
Flights from Williamson County Regional Airport to Columbia via Chicago O'Hare
- Ave. Duration
- 6h 20m
- When
- Every day
- Estimated price
- $270–1,300
Flights from Lambert–St. Louis International Airport to Columbia via Washington Dulles
- Ave. Duration
- 4h 54m
- When
- Every day
- Estimated price
- $330–1,600
Flights from Lambert–St. Louis International Airport to Columbia via Chicago O'Hare
- Ave. Duration
- 5h 7m
- When
- Every day
- Estimated price
- $290–1,400
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Carbondale Intermodal Station to Atlanta Bus Station
- Ave. Duration
- 8h 5m
- Frequency
- Once daily
- Estimated price
- $70–120
- Schedules at
- Flixbus USA
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Atlanta Bus Station to Camden
- Ave. Duration
- 5h
- Frequency
- 4 times a day
- Estimated price
- $35–75
- Website
- Greyhound
Bus from Cape Girardeau to St Louis Bus Station
- Ave. Duration
- 1h 50m
- Frequency
- Twice daily
- Estimated price
- $17–35
- Website
- Greyhound
Bus from Cape Girardeau to Memphis Bus Station
- Ave. Duration
- 3h 15m
- Frequency
- Twice daily
- Estimated price
- $27–55
- Website
- Greyhound
Bus from Memphis Bus Station to Atlanta Bus Station
- Ave. Duration
- 7h 35m
- Frequency
- 4 times a day
- Estimated price
- $55–110
- Website
- Greyhound
Bus from Atlanta Bus Station to Camden
- Ave. Duration
- 5h
- Frequency
- 4 times a day
- Estimated price
- $35–75
- Website
- Greyhound
- Phone
- +1 646-630-7186
- [email protected]
- Website
- Wanda Coach
Bus from Camden to Columbia, SC
- Ave. Duration
- 42 min
- Frequency
- Once daily
- Estimated price
- $28–40
- Website
- Wanda Coach
- Book at
- GotoBus.com
- Adult One Way
- $28–40
Bus from Camden to Columbia, SC
- Ave. Duration
- 42 min
- Frequency
- Once daily
- Estimated price
- $28–40
- Website
- Wanda Coach
- Book at
- GotoBus.com
- Adult One Way
- $28–40
- Ave. Duration
- 1h 6m
- Estimated price
- $100–160
Howard's Taxi Full Throttle
- Phone
- +1-573-270-9932
Howard's Taxi Full Throttle
- Phone
- +1-573-270-9932
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More Questions & Answers
Yes, the driving distance between Cape Girardeau to Lexington is 638 miles. It takes approximately 11h 14m to drive from Cape Girardeau to Lexington.
There are 343+ hotels available in Lexington.



