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How to get fromCape Girardeau to Louisvilleby bus (Greyhound), car, taxi, plane, train, or bus

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There are 6 ways to get from Cape Girardeau to Louisville by bus (Greyhound), car, taxi, plane, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    3. Take the bus from Evansville, IN to Louisville, KYbus bus
    9h 34m
    $84–148

  2. Drive 255.5 mi

    cheapest
    1. Drive from Cape Girardeau to Louisvillecar car 255.5 mi
    4h 51m
    $47–68

  3. Taxi to Williamson County Regional Airport, fly

    1. Take the taxi from Cape Girardeau to Williamson County Regional Airport (MWA)taxi taxi
    2. Fly from Williamson County Regional Airport (MWA) to Louisville International Airport (SDF)plane plane MWA - SDF
    8h 43m
    $244–810

  4. Taxi, train, bus

    1. Take the taxi from Cape Girardeau to Carbondaletaxi taxi
    2. Take the train from Carbondale to Champaign-Urbanatrain train
    3. Take the bus from Champaign Intermodal Trans Ctr to Indianapolis Union Stationbus bus
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    10h 20m
    $198–322

  5. Taxi to Barkley Regional Airport, fly

    1. Take the taxi from Cape Girardeau to Barkley Regional Airport (PAH)taxi taxi
    2. Fly from Barkley Regional Airport (PAH) to Louisville International Airport (SDF)plane plane PAH - SDF
    9h 51m
    $244–722

  6. Bus to Lambert–St. Louis International Airport, fly

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF)plane plane STL - SDF
    8h 9m
    $128–699

Williamson County Regional Airport (MWA) to Louisville International Airport (SDF) flights

Calendar11Weekly Planes
Duration6h 35mAverage Duration
Ticket$114Cheapest Price
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Questions & Answers

Map of how to get from Cape Girardeau to Louisville.ExpandLaunch map view
  • Distance: 399.7 mi
  • Duration: 9h 34m

What companies run services between Cape Girardeau, MO, USA and Louisville, KY, USA?

You can take a vehicle from Cape Girardeau to Louisville, KY via Cape Girardeau, St Louis Bus Station, and Evansville, IN in around 9h 34m.

Airlines
Train operators
Bus operators
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