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How to get fromCape Girardeau to Panama City Beachby bus, plane, bus (Greyhound, Flixbus), taxi, train, or car

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There are 9 ways to get from Cape Girardeau to Panama City Beach by bus, plane, bus (Greyhound, Flixbus), taxi, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Lambert–St. Louis International Airport, fly to Northwest Florida Beaches International Airport

    best
    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP)plane plane STL - ECP
    5h 50m
    $167–591

  2. Drive 615.1 mi

    cheapest
    1. Drive from Cape Girardeau to Panama City Beachcar car 615.1 mi
    12h 22m
    $113–163

  3. Bus

    1. Take the bus from Cape Girardeau to New Orleans Bus Stationbus bus
    2. Take the bus from New Orleans Bus Station to Mobile Bus Stationbus bus
    3. Take the bus from Mobile Bus Station to Panama City Beach Bus Stationbus bus
    22h 43m
    $146–280

  4. Taxi, train, bus

    1. Take the taxi from Cape Girardeau to Carbondaletaxi taxi
    2. Take the train from Carbondale to New Orleans Union Passenger Terminaltrain train
    3. Take the train from New Orleans Union Passenger Terminal to Biloxi Amtrak Statrain train
    4. Take the bus from Biloxi Transit Center to Mobile Bus Stationbus bus
    5. Take the bus from Mobile Bus Station to Panama City Beach Bus Stationbus bus
    23h 55m
    $359–665

  5. Bus to Lambert–St. Louis International Airport, fly to Destin–Fort Walton Beach Airport, drive

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Destin–Fort Walton Beach Airport (VPS)plane plane STL - VPS
    3. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama City Beachcar car
    6h 44m
    $122–532

  6. Fly Cape Girardeau Municipal Airport to Pensacola International Airport, bus

    1. Fly from Cape Girardeau Municipal Airport (CGI) to Pensacola International Airport (PNS)plane plane CGI - PNS
    2. Take the bus from Pensacola Airport to Panama City Beach Bus Stationbus bus
    5h 26m
    $178–539

  7. Taxi, bus to Nashville, fly to Northwest Florida Beaches International Airport

    1. Take the taxi from Cape Girardeau to Carbondale Intermodal Stationtaxi taxi
    2. Take the bus from Carbondale Intermodal Station to Nashville Bus Stationbus bus
    3. Fly from Nashville (BNA) to Northwest Florida Beaches International Airport (ECP)plane plane BNA - ECP
    8h 22m
    $250–634

  8. Bus to Midamerica St. Louis Airport, fly to Destin–Fort Walton Beach Airport, drive

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Midamerica St. Louis Airport (BLV) to Destin–Fort Walton Beach Airport (VPS)plane plane BLV - VPS
    3. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama City Beachcar car
    7h 6m
    $125–450

  9. Bus to Lambert–St. Louis International Airport, fly to Pensacola International Airport, bus

    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Pensacola International Airport (PNS)plane plane STL - PNS
    3. Take the bus from Pensacola Airport to Panama City Beach Bus Stationbus bus
    8h 51m
    $126–507

Lambert–St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP) flights

Calendar31Weekly Planes
Duration2h 57mAverage Duration
Ticket$91Cheapest Price
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Questions & Answers

Map of how to get from Cape Girardeau to Panama City Beach.ExpandLaunch map view
  • Distance: 783.4 mi
  • Duration: 5h 50m

What companies run services between Cape Girardeau, MO, USA and Panama City Beach, FL, USA?

You can take a vehicle from Cape Girardeau to Panama City Beach via Cape Girardeau, New Orleans Bus Station, Mobile Bus Station, and Panama City Beach Bus Station in around 22h 43m.

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