There are 5 ways to get from Cape Girardeau to Sedalia by bus, train, bus (Greyhound), car, taxi, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus, train
best- Take the bus from Cape Girardeau to St Louis Bus Stationbus Greyhound US1173
- Take the train from St. Louis to Sedalia Amtrak Stationtrain Lincoln Service Missouri River Runner / ...
6h 26m$84–173Drive 262.8 mi
cheapest- Drive from Cape Girardeau to Sedaliacar 262.8 mi
5h 18m$48–70Bus
- Take the bus from Cape Girardeau to St Louis Bus Stationbus Greyhound US1173
- Take the bus from St Louis Bus Station to La Montebus Greyhound US0175s
8h 31m$99–168Taxi to Williamson County Regional Airport, fly, drive
- Take the taxi from Cape Girardeau to Williamson County Regional Airport (MWA)taxi
- Fly from Williamson County Regional Airport (MWA) to Columbia Regional Airport (COU)plane MWA - COU
- Drive from Columbia Regional Airport (COU) to Sedaliacar
7h 30m$227–599Taxi to Barkley Regional Airport, fly, drive
- Take the taxi from Cape Girardeau to Barkley Regional Airport (PAH)taxi
- Fly from Barkley Regional Airport (PAH) to Columbia Regional Airport (COU)plane PAH - COU
- Drive from Columbia Regional Airport (COU) to Sedaliacar
8h 9m$227–561
Williamson County Regional Airport (MWA) to Columbia Regional Airport (COU) flights
Questions & Answers
The cheapest way to get from Cape Girardeau to Sedalia is to drive which costs $45 - $70 and takes 5h 18m.
The fastest way to get from Cape Girardeau to Sedalia is to drive which takes 5h 18m and costs $45 - $70.
No, there is no direct bus from Cape Girardeau to Sedalia. However, there are services departing from Cape Girardeau and arriving at La Monte via St Louis Bus Station. The journey, including transfers, takes approximately 8h 31m.
The distance between Cape Girardeau and Sedalia is 302 miles. The road distance is 264.4 miles.
The best way to get from Cape Girardeau to Sedalia without a car is to bus and train which takes 6h 26m and costs $80 - $180.
It takes approximately 6h 26m to get from Cape Girardeau to Sedalia, including transfers.
Cape Girardeau to Sedalia bus services, operated by Greyhound-us, depart from Cape Girardeau station.
Cape Girardeau to Sedalia bus services, operated by Greyhound-us, arrive at St Louis Bus Station.
Yes, the driving distance between Cape Girardeau to Sedalia is 264 miles. It takes approximately 5h 18m to drive from Cape Girardeau to Sedalia.
Book your Cape Girardeau to Sedalia bus tickets online with Omio.
What companies run services between Cape Girardeau, MO, USA and Sedalia, MO, USA?
You can take a vehicle from Cape Girardeau to Sedalia via Cape Girardeau, St Louis Bus Station, and La Monte in around 8h 31m.
- Website
- united.com
Flights from Williamson County Regional Airport to Columbia Regional Airport via Chicago O'Hare
- Ave. Duration
- 5h 45m
- When
- Every day
- Estimated price
- $80–420
Flights from Barkley Regional Airport to Columbia Regional Airport via Chicago O'Hare
- Ave. Duration
- 7h 23m
- When
- Every day
- Estimated price
- $70–370
- Website
- aa.com
Flights from Williamson County Regional Airport to Columbia Regional Airport via Chicago O'Hare
- Ave. Duration
- 6h 6m
- When
- Every day
- Estimated price
- $80–420
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from St. Louis to Sedalia Amtrak Station
- Ave. Duration
- 3h 32m
- Frequency
- Twice daily
- Estimated price
- $60–130
- Website
- https://www.amtrak.com/home.html
- Website
- greyhound.com
Bus from Cape Girardeau to St Louis Bus Station
- Ave. Duration
- 1h 50m
- Frequency
- Once daily
- Schedules at
- greyhound.com
Bus from Cape Girardeau to St Louis Bus Station
- Ave. Duration
- 1h 50m
- Frequency
- Once daily
- Schedules at
- greyhound.com
Bus from St Louis Bus Station to La Monte
- Ave. Duration
- 5h 25m
- Frequency
- Once daily
- Schedules at
- greyhound.com
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Cape Girardeau to St Louis Bus Station
- Ave. Duration
- 1h 50m
- Frequency
- Once daily
- Estimated price
- $17–35
- Website
- https://www.greyhound.com/
Bus from Cape Girardeau to St Louis Bus Station
- Ave. Duration
- 1h 50m
- Frequency
- Once daily
- Estimated price
- $17–35
- Website
- https://www.greyhound.com/
Bus from St Louis Bus Station to La Monte
- Ave. Duration
- 5h 25m
- Frequency
- Once daily
- Estimated price
- $35–75
- Website
- https://www.greyhound.com/
- Ave. Duration
- 1h 20m
- Estimated price
- $130–170
Howard's Taxi Full Throttle
- Phone
- +1-573-270-9932
Howard's Taxi Full Throttle
- Phone
- +1-573-270-9932
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More Questions & Answers
There are 17+ hotels available in Sedalia.






