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How to get fromCape Girardeau to Siesta Keyby bus, plane, taxi, car, bus (Greyhound, Flixbus), or train

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There are 6 ways to get from Cape Girardeau to Siesta Key by bus, plane, taxi, car, bus (Greyhound, Flixbus), or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Lambert–St. Louis International Airport, fly

    best
    1. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Sarasota–Bradenton International Airport (SRQ)plane plane STL - SRQ
    6h 59m
    $189–850

  2. Bus

    cheapest
    1. Take the bus from Cape Girardeau to Memphis Bus Stationbus bus
    2. Take the bus from Memphis Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Tampa Bus Stationbus bus
    4. Take the bus from Tampa Bus Station to Sarasota Cattlemen Transfer Centerbus bus
    25h 35m
    $165–301

  3. Taxi, bus

    1. Take the taxi from Cape Girardeau to Carbondale Intermodal Stationtaxi taxi
    2. Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Tampa Bus Stationbus bus
    4. Take the bus from Tampa Bus Station to Sarasota Cattlemen Transfer Centerbus bus
    22h 46m
    $244–360

  4. Drive  956 mi

    1. Drive from Cape Girardeau to Siesta Keycar car 956 mi
    16h 19m
    $175–252

  5. Taxi, bus to Nashville, fly

    1. Take the taxi from Cape Girardeau to Carbondale Intermodal Stationtaxi taxi
    2. Take the bus from Carbondale Intermodal Station to Nashville Bus Stationbus bus
    3. Fly from Nashville (BNA) to Sarasota–Bradenton International Airport (SRQ)plane plane BNA - SRQ
    9h 26m
    $267–928

  6. Bus, train

    1. Take the bus from Cape Girardeau to New Orleans Bus Stationbus bus
    2. Take the train from New Orleans Union Passenger Terminal to Gulfport Amtrak Statrain train
    3. Take the bus from Gulfport to Bradentonbus bus
    31h 30m
    $228–364

Lambert–St. Louis International Airport (STL) to Sarasota–Bradenton International Airport (SRQ) flights

Calendar45Weekly Planes
Duration4h 29mAverage Duration
Ticket$161Cheapest Price
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Questions & Answers

Map of how to get from Cape Girardeau to Siesta Key.ExpandLaunch map view
  • Distance: 1,049.1 mi
  • Duration: 6h 59m

What companies run services between Cape Girardeau, MO, USA and Siesta Key, FL, USA?

You can take a vehicle from Cape Girardeau to Ocean Blvd @ Avenida Madera via Cape Girardeau, Memphis Bus Station, Atlanta Bus Station, Tampa Bus Station, Sarasota Cattlemen Transfer Center, and Cattlemen Transit Station in around 25h 35m.

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