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How to get fromCarbondale to Des Moinesby bus (Amtrak, Flixbus, Greyhound), bus, train, car, or plane

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There are 8 ways to get from Carbondale to Des Moines by bus (Amtrak, Flixbus, Greyhound), bus, train, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Kansas City

    best
    1. Take the bus from Carbondale to St. Louisbus bus
    2. Take the bus from St Louis Bus Station to Kansas City Bus Stationbus bus
    3. Take the bus from Kansas City to Des Moinesbus bus
    11h 25m
    $99–196

  2. Drive  424.3 mi

    cheapest
    1. Drive from Carbondale to Des Moinescar car 424.3 mi
    8h 37m
    $78–112

  3. Bus, train

    1. Take the bus from Carbondale to St. Louisbus bus
    2. Take the train from St. Louis to Kansas Citytrain train
    3. Take the bus from Kansas City Bus Station to Des Moinesbus bus
    13h 37m
    $114–271

  4. Fly from Williamson County Regional Airport

    1. Fly from Williamson County Regional Airport (MWA) to Des Moines (DSM)plane plane MWA - DSM
    7h 14m
    $180–810

  5. Train, bus

    1. Take the train from Carbondale to Champaign-Urbanatrain train Illini / ...
    2. Take the bus from Champaign Intermodal Trans Ctr to Des Moinesbus bus Greyhound US0157S
    11h 35m
    $98–216

  6. Bus

    1. Take the bus from Carbondale to St. Louisbus bus
    2. Take the bus from St Louis Bus Station to Springfield SMTD Transfer Centerbus bus
    3. Take the bus from Springfield to Galesburg Amtrak Stationbus bus
    4. Take the bus from Galesburg to Des Moinesbus bus
    14h 31m
    $95–186

  7. Drive to Barkley Regional Airport, fly

    1. Drive from Carbondale to Barkley Regional Airport (PAH)car car
    2. Fly from Barkley Regional Airport (PAH) to Des Moines (DSM)plane plane PAH - DSM
    6h 54m
    $139–689

  8. Bus to Lambert–St. Louis International Airport, fly

    1. Take the bus from Carbondale to St. Louisbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Des Moines (DSM)plane plane STL - DSM
    7h 34m
    $154–815

Carbondale to Des Moines by bus

Calendar12Weekly Buses
Duration11h 25mAverage Duration
Ticket$99Cheapest Price
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Questions & Answers

Map of how to get from Carbondale to Des Moines.ExpandLaunch map view
  • Distance: 537.5 mi
  • Duration: 11h 25m

What companies run services between Carbondale, IL, USA and Des Moines, IA, USA?

You can take a bus from Carbondale to Des Moines via St. Louis, St Louis Bus Station, Kansas City Bus Station, and Kansas City in around 11h 25m. Alternatively, American Airlines flies from Williamson County Regional Airport (MWA) to Des Moines (DSM) twice daily.

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