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How to get fromCarlisle to Chicagoby bus, plane, train (Amtrak), bus (Flixbus), car, or bus (Greyhound)

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There are 6 ways to get from Carlisle to Chicago by bus, plane, train (Amtrak), bus (Flixbus), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Harrisburg International Airport, fly

    best
    1. Take the bus from Hanover St & High St to Market Square Transfer Centerbus bus
    2. Fly from Harrisburg International Airport (MDT) to Chicago O'Hare International Airport (ORD)plane plane MDT - ORD
    5h 48m
    $115–659

  2. Bus to Penn State University Park Airport, fly

    cheapest
    1. Take the bus from Harrisburg Bus Station to State College Regional Airportbus bus
    2. Fly from Penn State University Park Airport (SCE) to Chicago O'Hare International Airport (ORD)plane plane SCE - ORD
    7h 26m
    $68–322

  3. Train (Amtrak)

    1. Take the train from Harrisburg to Pittsburgh Amtrak Stationtrain train Pennsylvanian
    2. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train Floridian
    18h 16m
    $227–482

  4. Bus (Flixbus)

    1. Take the bus from Harrisburg Bus Station to Chicago Bus Stationbus bus FlixBus N2640 / ...
    18h 31m
    $122–212

  5. Drive 642.6 mi

    1. Drive from Carlisle to Chicagocar car 642.6 mi
    10h 33m
    $118–170

  6. Bus via Baltimore (Greyhound)

    1. Take the bus from Harrisburg Bus Station to Baltimore Downtown Bus Stationbus bus Greyhound US0430
    2. Take the bus from Baltimore Downtown Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    23h 26m
    $123–244

Carlisle to Chicago by bus, foot, and train (Amtrak)

Calendar7Weekly Services
Duration18h 16mAverage Duration
Ticket$227Cheapest Price
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Questions & Answers

Map of how to get from Carlisle to Chicago.ExpandLaunch map view
  • Distance: 641.5 mi
  • Duration: 5h 48m

What companies run services between Carlisle, PA, USA and Chicago, IL, USA?

You can take a bus from Hanover St & High St to Chicago Union Station via Market Square Transfer Center, Harrisburg, and Pittsburgh Amtrak Station in around 18h 16m. Alternatively, Flixbus USA operates a bus from Harrisburg Bus Station to Chicago Bus Station once daily. Tickets cost $120–210 and the journey takes 16h 30m.

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