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How to get fromCarlisle to Chicago Union Stationby bus, plane, train (Amtrak), bus (Flixbus), car, or bus (Greyhound)

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There are 6 ways to get from Carlisle to Chicago Union Station by bus, plane, train (Amtrak), bus (Flixbus), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Harrisburg International Airport, fly

    best
    1. Take the bus from Hanover St & High St to Market Square Transfer Centerbus bus
    2. Fly from Harrisburg International Airport (MDT) to Chicago O'Hare International Airport (ORD)plane plane MDT - ORD
    6h 1m
    $60–319

  2. Train (Amtrak)

    1. Take the train from Harrisburg to Pittsburgh Amtrak Stationtrain train Pennsylvanian
    2. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train Floridian
    18h 16m
    $217–472

  3. Bus (Flixbus)

    1. Take the bus from Harrisburg Bus Station to Chicago Bus Stationbus bus FlixBus N2640 / ...
    18h 40m
    $112–192

  4. Drive 643.1 mi

    1. Drive from Carlisle to Chicago Union Stationcar car 643.1 mi
    10h 33m
    $118–170

  5. Bus to Penn State University Park Airport, fly

    1. Take the bus from Harrisburg Bus Station to State College Regional Airportbus bus
    2. Fly from Penn State University Park Airport (SCE) to Chicago O'Hare International Airport (ORD)plane plane SCE - ORD
    7h 38m
    $67–330

  6. Bus via Baltimore (Greyhound)

    1. Take the bus from Harrisburg Bus Station to Baltimore Downtown Bus Stationbus bus Greyhound US0430
    2. Take the bus from Baltimore Downtown Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    23h 35m
    $123–244

Carlisle to Chicago Union Station by bus, foot, and train (Amtrak)

Calendar7Weekly Services
Duration18h 16mAverage Duration
Ticket$217Cheapest Price
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Questions & Answers

Map of how to get from Carlisle to Chicago Union Station.ExpandLaunch map view
  • Distance: 642.4 mi
  • Duration: 6h 1m

What companies run services between Carlisle, PA, USA and Chicago Union Station, IL, USA?

You can take a bus from Hanover St & High St to Chicago Union Station via Market Square Transfer Center, Harrisburg, and Pittsburgh Amtrak Station in around 18h 16m. Alternatively, Flixbus USA operates a bus from Harrisburg Bus Station to Chicago Bus Station once daily. Tickets cost $110–190 and the journey takes 16h 30m.

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