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How to get fromCarlisle to Durhamby bus (Greyhound, Flixbus), bus, train, car, plane, bus (Greyhound), or train (Amtrak)

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There are 7 ways to get from Carlisle to Durham by bus (Greyhound, Flixbus), bus, train, car, plane, bus (Greyhound), or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Harrisburg Bus Station to Washington Union Stationbus bus Greyhound US0430
    2. Take the bus from Washington Union Station to Durhambus bus FlixBus N2471 / ...
    12h 1m
    $59–122

  2. Bus via Durham, NC - 3446 Hillsborough Rd

    cheapest
    1. Take the bus from Harrisburg Bus Station to Washington Union Stationbus bus Greyhound US0430
    2. Take the bus from Washington, DC - 2305 Pennsylvania Ave to Durham, NC - 3446 Hillsborough Rdbus bus New York
    12h 26m
    $47–96

  3. Bus, train

    1. Take the bus from Harrisburg Bus Station to Washington Union Stationbus bus Greyhound US0430
    2. Take the train from Washington Union Station to Durham Amtrak Stationtrain train Carolinian
    13h 6m
    $119–257

  4. Drive 359.6 mi

    1. Drive from Carlisle to Durhamcar car 359.6 mi
    6h 31m
    $66–95

  5. Bus to Harrisburg International Airport, fly, line 700 bus

    1. Take the bus from Hanover St & High St to Market Square Transfer Centerbus bus
    2. Fly from Harrisburg International Airport (MDT) to Raleigh-Durham International Airport (RDU)plane plane MDT - RDU
    3. Take the bus from Regional Transit Center to Duke St at Jackson Stbus bus
    7h 40m
    $129–760

  6. Train (Amtrak)

    1. Take the train from Harrisburg to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to Washington Union Stationtrain train
    3. Take the train from Washington Union Station to Durham Amtrak Stationtrain train
    13h 49m
    $162–942

  7. Bus, train to Philadelphia International Airport, fly, line 700 bus

    1. Take the bus from Hanover St & High St to Market Square Transfer Centerbus bus
    2. Take the train from Harrisburg to 30th Street Stationtrain train
    3. Fly from Philadelphia International Airport (PHL) to Raleigh-Durham International Airport (RDU)plane plane PHL - RDU
    4. Take the bus from Regional Transit Center to Duke St at Jackson Stbus bus
    8h 17m
    $116–451

Carlisle to Durham by bus and foot

Calendar7Weekly Services
Duration12h 1mAverage Duration
Ticket$59Cheapest Price
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Questions & Answers

Map of how to get from Carlisle to Durham.ExpandLaunch map view
  • Distance: 420.6 mi
  • Duration: 12h 1m

What companies run services between Carlisle, PA, USA and Durham, NC, USA?

You can take a bus from Hanover St & High St to Durham via Market Square Transfer Center, Harrisburg Bus Station, and Washington Union Station in around 12h 1m. Alternatively, you can take a bus from Hanover St & High St to Durham Amtrak Station via Market Square Transfer Center, Harrisburg, 30th Street Station, and Washington Union Station in around 13h 49m.

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