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How to get fromCarlisle to Knoxvilleby plane, train, bus, car, or bus (Flixbus)

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There are 6 ways to get from Carlisle to Knoxville by plane, train, bus, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Harrisburg International Airport

    best
    1. Fly from Harrisburg International Airport (MDT) to Mcghee Tyson Airport (TYS)plane plane MDT - TYS
    7h 1m
    $178–774

  2. Drive 518.9 mi

    cheapest
    1. Drive from Carlisle to Knoxvillecar car 518.9 mi
    8h 30m
    $95–137

  3. Train, bus

    1. Take the train from Harrisburg to Ny Moynihan Train Hall At Penn Stationtrain train Keystone Service / ...
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    19h 7m
    $195–295

  4. Bus to Penn State University Park Airport, fly

    1. Take the bus from Harrisburg Bus Station to State College Regional Airportbus bus
    2. Fly from Penn State University Park Airport (SCE) to Mcghee Tyson Airport (TYS)plane plane SCE - TYS
    8h 57m
    $190–795

  5. Train to Philadelphia International Airport, fly

    1. Take the train from Harrisburg to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Mcghee Tyson Airport (TYS)plane plane PHL - TYS
    7h 40m
    $250–1,095

  6. Bus

    1. Take the bus from Harrisburg Bus Station to New York City Chinatownbus bus FlixBus N2640
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    23h 47m
    $131–172

Harrisburg International Airport (MDT) to Mcghee Tyson Airport (TYS) flights

Calendar99Weekly Planes
Duration5h 5mAverage Duration
Ticket$120Cheapest Price
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Questions & Answers

Map of how to get from Carlisle to Knoxville.ExpandLaunch map view
  • Distance: 540.3 mi
  • Duration: 7h 1m

What companies run services between Carlisle, PA, USA and Knoxville, TN, USA?

United Airlines, American Airlines, and two other airlines fly from Harrisburg International Airport (MDT) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from Hanover St & High St to Knoxville Station Hall of Fame via Market Square Transfer Center, Harrisburg Bus Station, New York, NY, Knoxville, TN, Walmart, and Charlie Haun WB Aft Washington PK in around 23h 47m.

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