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How to get fromCarlisle to Roanokeby bus, train, bus (Greyhound), car, plane, or train (Amtrak)

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There are 6 ways to get from Carlisle to Roanoke by bus, train, bus (Greyhound), car, plane, or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, train

    best
    1. Take the bus from Harrisburg Bus Station to Washington Union Stationbus bus Greyhound US0430
    2. Take the train from Washington Union Station to Roanoketrain train Northeast Regional
    11h 26m
    $89–187

  2. Drive 269.1 mi

    cheapest
    1. Drive from Carlisle to Roanokecar car 269.1 mi
    4h 35m
    $50–71

  3. Bus (Greyhound)

    1. Take the bus from Harrisburg Bus Station to Baltimore Downtown Bus Stationbus bus Greyhound US0430
    2. Take the bus from Baltimore Downtown Bus Station to Roanoke Bus Stopbus bus Greyhound US0600
    12h 10m
    $53–105

  4. Fly

    1. Fly from Harrisburg International Airport (MDT) to Roanoke Regional Airport-Woodrum Field (ROA)plane plane MDT - ROA
    7h 27m
    $102–659

  5. Train (Amtrak)

    1. Take the train from Harrisburg to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to Washington Union Stationtrain train
    3. Take the train from Washington Union Station to Roanoketrain train
    12h 9m
    $132–872

  6. Bus via Washington

    1. Take the bus from Harrisburg Bus Station to Washington Union Stationbus bus Greyhound US0430
    2. Take the bus from Washington Union Station to Salem VDOT Park & Ridebus bus Highlands Rhythm
    12h 34m
    $55–91

Carlisle to Roanoke by bus, foot, and train

Calendar14Weekly Services
Duration11h 26mAverage Duration
Ticket$89Cheapest Price
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Questions & Answers

Map of how to get from Carlisle to Roanoke.ExpandLaunch map view
  • Distance: 359.2 mi
  • Duration: 11h 26m

What companies run services between Carlisle, PA, USA and Roanoke, VA, USA?

You can take a bus from Hanover St & High St to Roanoke Bus Stop via Market Square Transfer Center, Harrisburg Bus Station, and Baltimore Downtown Bus Station in around 12h 10m. Alternatively, United Airlines, American Airlines, and Delta fly from Harrisburg International Airport (MDT) to Roanoke Regional Airport-Woodrum Field (ROA) hourly.

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Need to know: Greyhound

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