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How to get fromCarlisle to St. Louisby plane, bus (Greyhound), train (Amtrak), car, or train

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There are 5 ways to get from Carlisle to St. Louis by plane, bus (Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Harrisburg International Airport

    best
    1. Fly from Harrisburg International Airport (MDT) to Lambert–St. Louis International Airport (STL)plane plane MDT - STL
    7h 52m
    $246–1,207

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Harrisburg Bus Station to St Louis Bus Stationbus bus Greyhound US0421
    20h 6m
    $122–232

  3. Train (Amtrak)

    1. Take the train from Harrisburg to Pittsburgh Amtrak Stationtrain train
    2. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    24h 2m
    $312–682

  4. Drive 766.1 mi

    1. Drive from Carlisle to St. Louiscar car 766.1 mi
    13h 6m
    $140–202

  5. Train to Philadelphia International Airport, fly

    1. Take the train from Harrisburg to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL)plane plane PHL - STL
    8h 21m
    $188–878

Carlisle to St. Louis by bus and foot (Greyhound)

Calendar28Weekly Services
Duration20h 6mAverage Duration
Ticket$122Cheapest Price
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Questions & Answers

Map of how to get from Carlisle to St. Louis.ExpandLaunch map view
  • Distance: 776.7 mi
  • Duration: 7h 52m

What companies run services between Carlisle, PA, USA and St. Louis, MO, USA?

Delta, United Airlines, and American Airlines fly from Harrisburg International Airport (MDT) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, Greyhound USA operates a bus from Harrisburg Bus Station to St Louis Bus Station 4 times a day. Tickets cost $120–230 and the journey takes 18h 5m.

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