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How to get fromCarlisle to Winston-Salemby plane, bus, train, bus (Greyhound), car, or bus (Greyhound, Flixbus)

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There are 8 ways to get from Carlisle to Winston-Salem by plane, bus, train, bus (Greyhound), car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Harrisburg International Airport to Piedmont Triad International Airport

    best
    1. Fly from Harrisburg International Airport (MDT) to Piedmont Triad International Airport (GSO)plane plane MDT - GSO
    7h 27m
    $107–577

  2. Drive 373.3 mi

    cheapest
    1. Drive from Carlisle to Winston-Salemcar car 373.3 mi
    6h 49m
    $69–99

  3. Bus, train

    1. Take the bus from Harrisburg Bus Station to Washington Union Stationbus bus Greyhound US0430
    2. Take the train from Washington Union Station to High Pointtrain train Crescent / ...
    14h 18m
    $111–242

  4. Bus (Greyhound)

    1. Take the bus from Harrisburg Bus Station to Baltimore Downtown Bus Stationbus bus Greyhound US0430
    2. Take the bus from Baltimore Downtown Bus Station to Winston Salem(Trans Center)bus bus Greyhound US0670
    14h 36m
    $73–144

  5. Fly Harrisburg International Airport to Charlotte Douglas International Airport, bus

    1. Fly from Harrisburg International Airport (MDT) to Charlotte Douglas International Airport (CLT)plane plane MDT - CLT
    2. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    7h 46m
    $94–540

  6. Train to Philadelphia International Airport, fly to Piedmont Triad International Airport

    1. Take the train from Harrisburg to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Piedmont Triad International Airport (GSO)plane plane PHL - GSO
    8h 10m
    $174–848

  7. Train, bus

    1. Take the train from Harrisburg to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to Greensborotrain train
    3. Take the bus from Greensboro Bus Stop to Winston Salem(Trans Center)bus bus
    15h
    $166–360

  8. Bus via Fredericksburg

    1. Take the bus from Harrisburg Bus Station to Washington Union Stationbus bus
    2. Take the bus from Washington Union Station to Fredericksburgbus bus
    3. Take the bus from Fredericksburg to Greensboro Bus Stopbus bus
    18h 12m
    $83–147

Carlisle to Winston-Salem by bus, foot, and train

Calendar7Weekly Services
Duration14h 18mAverage Duration
Ticket$111Cheapest Price
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Questions & Answers

Map of how to get from Carlisle to Winston-Salem.ExpandLaunch map view
  • Distance: 385 mi
  • Duration: 7h 27m

What companies run services between Carlisle, PA, USA and Winston-Salem, NC, USA?

United Airlines, American Airlines, and Delta fly from Harrisburg International Airport (MDT) to Piedmont Triad International Airport (GSO) hourly. Alternatively, you can take a bus from Hanover St & High St to Winston Salem(Trans Center) via Market Square Transfer Center, Harrisburg Bus Station, and Baltimore Downtown Bus Station in around 14h 36m.

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