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How to get fromCary to Des Moinesby plane, train, bus, bus (Flixbus, Greyhound), or car

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There are 8 ways to get from Cary to Des Moines by plane, train, bus, bus (Flixbus, Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Raleigh-Durham International Airport

    best
    1. Fly from Raleigh-Durham International Airport (RDU) to Des Moines (DSM)plane plane RDU - DSM
    6h 13m
    $192–826

  2. Train, bus

    1. Take the train from Cary to Chicago Union Stationtrain train Floridian
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    32h 51m
    $405–810

  3. Bus

    1. Take the bus from Durham to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    33h 34m
    $220–426

  4. Drive 1,069.9 mi

    1. Drive from Cary to Des Moinescar car 1,069.9 mi
    18h 37m
    $196–282

  5. Train to Piedmont Triad International Airport, fly

    1. Take the train from Cary to Greensborotrain train
    2. Fly from Piedmont Triad International Airport (GSO) to Des Moines (DSM)plane plane GSO - DSM
    7h 13m
    $261–1,059

  6. Train to Charlotte Douglas International Airport, fly

    1. Take the train from Cary to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Des Moines (DSM)plane plane CLT - DSM
    7h 43m
    $247–985

  7. Train, train to Fayetteville Municipal Airport, fly

    1. Take the train from Cary to Selma Stationtrain train
    2. Take the train from Selma Station to Fayetteville Amtrak Stationtrain train
    3. Fly from Fayetteville Municipal Airport (FAY) to Des Moines (DSM)plane plane FAY - DSM
    8h 41m
    $212–801

  8. Train, bus via Galesburg

    1. Take the train from Cary to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    3. Take the bus from Galesburg to Des Moinesbus bus
    34h 43m
    $435–885

Cary to Des Moines by train, foot, and bus

Calendar7Weekly Services
Duration32h 51mAverage Duration
Ticket$405Cheapest Price
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Questions & Answers

Map of how to get from Cary to Des Moines.ExpandLaunch map view
  • Distance: 910.1 mi
  • Duration: 6h 13m

What companies run services between Cary, NC, USA and Des Moines, IA, USA?

Southwest Airlines, Delta, and two other airlines fly from Raleigh-Durham International Airport (RDU) to Des Moines (DSM) hourly. Alternatively, you can take a bus from Cary Depot to Des Moines via Regional Transit Center, Durham Station, Durham, Atlanta Bus Station, and Indianapolis Union Station in around 33h 34m.

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