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How to get fromCary to Louisvilleby plane, bus, train, car, or bus (Greyhound, Flixbus)

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There are 7 ways to get from Cary to Louisville by plane, bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Raleigh-Durham International Airport

    best
    1. Fly from Raleigh-Durham International Airport (RDU) to Louisville International Airport (SDF)plane plane RDU - SDF
    4h 54m
    $102–608

  2. Bus via Winston-Salem

    cheapest
    1. Take the bus from Health Sciences Library on S Columbia to Coble Transportation Centerbus bus 4
    2. Take the bus from Winston Salem(Trans Center) to Columbus - Mound Stbus bus
    3. Take the bus from Columbus - Downtown - Mound St to Louisville, KY Bus Stationbus bus
    21h 10m
    $68–162

  3. Train, bus (Amtrak)

    1. Take the train from Cary to Greensborotrain train
    2. Take the train from Greensboro to Charlottesvilletrain train
    3. Take the train from Charlottesville to Indianapolistrain train
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    25h 34m
    $247–569

  4. Drive 514.3 mi

    1. Drive from Cary to Louisvillecar car 514.3 mi
    9h 48m
    $94–136

  5. Train to Charlotte Douglas International Airport, fly

    1. Take the train from Cary to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Louisville International Airport (SDF)plane plane CLT - SDF
    7h 45m
    $143–708

  6. Bus

    1. Take the bus from Durham to Charlotte Bus Stationbus bus
    2. Take the bus from Charlotte Bus Station to Wilson & Ferrell Shell Station - Columbusbus bus
    3. Take the bus from N Wilson Rd & Ferrell Pl - Columbus to Louisville, KY Bus Stationbus bus
    21h 29m
    $110–236

  7. Train, bus via Toledo

    1. Take the train from Cary to Toledotrain train
    2. Take the bus from Toledo Bus Stop to Cincinnati Bus Stationbus bus
    3. Take the bus from Greyhound Station Cincinnati to Louisville, KY Bus Stationbus bus
    27h 50m
    $263–615

Cary to Louisville by train and bus (Amtrak)

Calendar3Weekly Services
Duration25h 34mAverage Duration
Ticket$247Cheapest Price
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Questions & Answers

Map of how to get from Cary to Louisville.ExpandLaunch map view
  • Distance: 435.1 mi
  • Duration: 4h 54m

What companies run services between Cary, NC, USA and Louisville, KY, USA?

Breeze Airways, American Airlines, and three other airlines fly from Raleigh-Durham International Airport (RDU) to Louisville International Airport (SDF) every 2 hours. Alternatively, you can take a bus from Cary Depot to Louisville, KY Bus Station via Regional Transit Center, Pittsboro St at Credit Union, Health Sciences Library on S Columbia, Coble Transportation Center, Winston-Salem Transportation Center, Winston Salem(Trans Center), and Columbus - Downtown - Mound St in around 21h 10m.

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