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How to get fromCary to Louisvilleby plane, bus (Flixbus, Greyhound, Amtrak), train, bus, or car

Find Transport to Louisville

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There are 7 ways to get from Cary to Louisville by plane, bus (Flixbus, Greyhound, Amtrak), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Raleigh-Durham International Airport

    best
    1. Fly from Raleigh-Durham International Airport (RDU) to Louisville International Airport (SDF)plane plane RDU - SDF
    4h 54m
    $116–708

  2. Drive  514.3 mi

    cheapest
    1. Drive from Cary to Louisvillecar car 514.3 mi
    9h 50m
    $94–136

  3. Bus

    1. Take the bus from Durham to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville to Louisville, KYbus bus
    19h 44m
    $126–220

  4. Train, bus (Amtrak)

    1. Take the train from Cary to Greensborotrain train
    2. Take the train from Greensboro to Charlottesvilletrain train
    3. Take the train from Charlottesville to Indianapolistrain train
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    25h 4m
    $482–806

  5. Train to Charlotte Douglas International Airport, fly

    1. Take the train from Cary to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Louisville International Airport (SDF)plane plane CLT - SDF
    7h 39m
    $187–748

  6. Train, bus via Columbus

    1. Take the train from Cary to Greensborotrain train
    2. Take the bus from Greensboro to Winston-Salembus bus
    3. Take the bus from Winston Salem to Columbusbus bus
    4. Take the bus from Columbus to Indianapolis Union Stationbus bus
    5. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    21h 21m
    $137–255

  7. Train, bus via Arlington (Amtrak)

    1. Take the train from Cary to Alexandriatrain train
    2. Take the train from Alexandria to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    28h 1m
    $578–899

Cary to Louisville by bus

Calendar14Weekly Buses
Duration19h 44mAverage Duration
Ticket$126Cheapest Price
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Comparing Your Travel Options

Map of how to get from Cary to Louisville.ExpandLaunch map view
  • Distance: 435.1 mi
  • Duration: 4h 54m

What companies run services between Cary, NC, USA and Louisville, KY, USA?

Breeze Airways, Delta, and three other airlines fly from Raleigh-Durham International Airport (RDU) to Louisville International Airport (SDF) every 3 hours. Alternatively, you can take a bus from Cary Depot to Louisville, KY via Regional Transit Center, Durham Station, Durham, Atlanta Bus Station, and Nashville in around 19h 44m.

Airlines
Train operators
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