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How to get fromCayo Guillermo to Santa Claraby car or bus

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There are 3 ways to get from Cayo Guillermo to Santa Clara by car or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive 255.3 km

    best
    1. Drive from Cayo Guillermo to Santa Claracar car 255.3 km
    4h 8m
    $29–42

  2. Drive, bus

    1. Drive from Cayo Guillermo to Cayo Santa Maríacar car
    2. Take the bus from Cayo Santa María to Santa Clarabus bus Santa Clara
    5h 54m
    $37–58

  3. Drive, bus via Valentin Perla Blanca

    1. Drive from Cayo Guillermo to Valentin Perla Blancacar car
    2. Take the bus from Cayo Santa María to Santa Clarabus bus Santa Clara
    7h 17m
    $37–59

Questions & Answers

Map of how to get from Cayo Guillermo to Santa Clara.ExpandLaunch map view
  • Distance: 255.3 km
  • Duration: 4h 8m

What companies run services between Cayo Guillermo, Cuba and Santa Clara, Cuba?

You can drive from Cayo Guillermo to Santa Clara in around 4h 8m.

Operators

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