There are 3 ways to get from Cayo Guillermo to Santa Clara by car or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Drive 255.3 km
best- Drive from Cayo Guillermo to Santa Claracar 255.3 km
4h 8m$30–44Drive, bus
- Drive from Cayo Guillermo to Cayo Santa Maríacar
- Take the bus from Cayo Santa María to Santa Clarabus Santa Clara
5h 54m$37–59Drive, bus via Valentin Perla Blanca
- Drive from Cayo Guillermo to Valentin Perla Blancacar
- Take the bus from Cayo Santa María to Santa Clarabus Santa Clara
7h 17m$38–60
Comparing Your Travel Options
The cheapest way to get from Cayo Guillermo to Santa Clara is to drive which costs $29 - $45 and takes 4h 8m.
The fastest way to get from Cayo Guillermo to Santa Clara is to drive which takes 4h 8m and costs $29 - $45.
The distance between Cayo Guillermo and Santa Clara is 255 km. The road distance is 255.3 km.
It takes approximately 4h 8m to drive 255.3 km from Cayo Guillermo to Santa Clara.
Yes, the driving distance between Cayo Guillermo to Santa Clara is 255 km. It takes approximately 4h 8m to drive from Cayo Guillermo to Santa Clara.
What companies run services between Cayo Guillermo, Cuba and Santa Clara, Cuba?
You can drive from Cayo Guillermo to Santa Clara in around 4h 8m.
- Phone
- +53 59 89 0616
- [email protected]
- Website
- Viazul
Bus from Cayo Santa María to Santa Clara
- Ave. Duration
- 2h 10m
- Frequency
- Once daily
- Estimated price
- $8–16
- Website
- Viazul
Bus from Cayo Santa María to Santa Clara
- Ave. Duration
- 2h 10m
- Frequency
- Once daily
- Estimated price
- $8–16
- Website
- Viazul
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