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How to get fromCayo Santa María to Colónby bus, plane, or shuttle

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There are 4 ways to get from Cayo Santa María to Colón by bus, plane, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, bus to José Martí International Airport, fly to Tocumen International Airport, shuttle

    best
    1. Take the bus from Cayo Santa María to Santa Clarabus bus
    2. Take the bus from Santa Clara to Havana Airportbus bus
    3. Fly from José Martí International Airport (HAV) to Tocumen International Airport (PTY)plane plane HAV - PTY
    4. Take a shuttle bus from Aeropuerto Internacional de Tocumen to Colónshuttle bus
    16h 42m
    $1,064–7,131

  2. Bus to Abel Santamaría Airport, fly to Tocumen International Airport, shuttle

    cheapest
    1. Take the bus from Cayo Santa María to Santa Clarabus bus
    2. Fly from Abel Santamaría Airport (SNU) to Tocumen International Airport (PTY)plane plane SNU - PTY
    3. Take a shuttle bus from Aeropuerto Internacional de Tocumen to Colónshuttle bus
    12h 45m
    $206–607

  3. Bus, bus to José Martí International Airport, fly to Panama Pacific International Airport

    1. Take the bus from Cayo Santa María to Santa Clarabus bus
    2. Take the bus from Santa Clara to Havana Airportbus bus
    3. Fly from José Martí International Airport (HAV) to Panama Pacific International Airport (BLB)plane plane HAV - BLB
    4. Take the bus from Terminal de Albrook to Colónbus bus
    15h 1m
    $535–1,169

  4. Bus, bus to Ignacio Agramonte International Airport, fly to Tocumen International Airport, shuttle

    1. Take the bus from Cayo Santa María to Santa Clarabus bus
    2. Take the bus from Santa Clara to Camagüeybus bus
    3. Fly from Ignacio Agramonte International Airport (CMW) to Tocumen International Airport (PTY)plane plane CMW - PTY
    4. Take a shuttle bus from Aeropuerto Internacional de Tocumen to Colónshuttle bus
    17h 57m
    $206–607

José Martí International Airport (HAV) to Tocumen International Airport (PTY) flights

Calendar23Weekly Planes
Duration3h 40mAverage Duration
Ticket$224Cheapest Price
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Comparing Your Travel Options

Map of how to get from Cayo Santa María to Colón.ExpandLaunch map view
  • Distance: 2,061.8 km
  • Duration: 16h 42m

What companies run services between Cayo Santa María, Villa Clara, Cuba and Colón, Panama?

There is no direct connection from Cayo Santa María to Colón. However, you can take the bus to Santa Clara, take the bus to Havana Airport, walk to José Martí International Airport (HAV) airport, fly to Tocumen International Airport (PTY), walk to Aeropuerto Internacional de Tocumen, then take the shuttle to Colón. Alternatively, you can take the bus to Santa Clara, take the bus to Havana Airport, walk to José Martí International Airport (HAV) airport, fly to Panama Pacific International Airport (BLB), take the taxi to Terminal de Albrook, then take the bus to Colón.

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