Rome2Rio

How to get fromChampaign to Mayo Clinicby plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Flixbus, Greyhound)

Find Transport to Mayo Clinic

See all options

There are 8 ways to get from Champaign to Mayo Clinic by plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from University Of Illinois Willard Airport

    best
    1. Fly from University Of Illinois Willard Airport (CMI) to Rochester (RST)plane plane CMI - RST
    5h 18m
    $73–342

  2. Bus to Central Illinois Regional Airport At Bloomington-Normal, fly

    cheapest
    1. Take the bus from Champaign Intermodal Trans Ctr to Bloomington-Normalbus bus
    2. Fly from Central Illinois Regional Airport At Bloomington-Normal (BMI) to Rochester (RST)plane plane BMI - RST
    9h 29m
    $59–336

  3. Bus

    1. Take the bus from Isr to Downtown Chicagobus bus
    2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    12h 15m
    $129–187

  4. Train, bus

    1. Take the train from Champaign-Urbana to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochester, MNbus bus
    13h 45m
    $200–394

  5. Drive 417.6 mi

    1. Drive from Champaign to Mayo Cliniccar car 417.6 mi
    7h 57m
    $77–111

  6. Train to Chicago O'Hare International Airport, fly

    1. Take the train from Champaign-Urbana to Chicago Union Stationtrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    7h 27m
    $89–379

  7. Train, bus via Madison

    1. Take the train from Champaign-Urbana to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    12h 20m
    $117–214

  8. Bus via Lake Delton

    1. Take the bus from Champaign Intermodal Trans Ctr to Chicagobus bus
    2. Take the bus from Chicago Bus Station to Wisconsin Dellsbus bus
    3. Take the bus from Wisconsin Dells to Rochester, MNbus bus
    13h 34m
    $101–169

Champaign to Mayo Clinic by train, bus, and foot

Calendar21Weekly Services
Duration13h 45mAverage Duration
Ticket$200Cheapest Price
See schedules

Questions & Answers

Map of how to get from Champaign to Mayo Clinic.ExpandLaunch map view
  • Distance: 360 mi
  • Duration: 5h 18m

What companies run services between Champaign, IL, USA and Mayo Clinic, MN, USA?

American Airlines flies from University Of Illinois Willard Airport (CMI) to Rochester (RST) 3 times a day. Alternatively, you can take a bus from Isr to Mayo Clinic via Downtown Chicago, Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 12h 15m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers