There are 7 ways to get from Champaign to Mayo Clinic by plane, bus (Flixbus, Greyhound), train, bus, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from University Of Illinois Willard Airport
best- Fly from University Of Illinois Willard Airport (CMI) to Rochester (RST)plane CMI - RST
5h 9m$74–402Bus to Central Illinois Regional Airport At Bloomington-Normal, fly
cheapest- Take the bus from Champaign Intermodal Trans Ctr to Bloomington-Normalbus
- Fly from Central Illinois Regional Airport At Bloomington-Normal (BMI) to Rochester (RST)plane BMI - RST
11h 41m$62–395Bus via Milwaukee
- Take the bus from Champaign Intermodal Trans Ctr to Chicago Bus Stationbus
- Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus
- Take the bus from Milwaukee to Rochesterbus
11h 46m$129–185Train, bus
- Take the train from Champaign-Urbana to Chicago Union Stationtrain
- Take the train from Chicago Union Station to St. Paul-Minneapolistrain
- Take the bus from St. Paul to Rochesterbus
13h 38m$318–498Drive 417.7 mi
- Drive from Champaign to Mayo Cliniccar 417.7 mi
7h 57m$72–104Train, bus via Madison
- Take the train from Champaign-Urbana to Chicago Union Stationtrain
- Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus
- Take the bus from Madison to Rochesterbus
12h 20m$145–238Bus
- Take the bus from Champaign Intermodal Trans Ctr to Chicagobus
- Take the bus from Chicago Bus Station to Madisonbus
- Take the bus from Madison to Rochesterbus
13h 56m$99–158
Champaign to Mayo Clinic by bus and foot
Comparing Your Travel Options
The cheapest way to get from Champaign to Mayo Clinic is to drive which costs $70 - $110 and takes 7h 57m.
The fastest way to get from Champaign to Mayo Clinic is to fly which takes 5h 9m and costs $70 - $410.
No, there is no direct bus from Champaign to Mayo Clinic. However, there are services departing from Champaign Intermodal Trans Ctr and arriving at Rochester via Chicago Bus Station and Milwaukee. The journey, including transfers, takes approximately 11h 46m.
The distance between Champaign and Mayo Clinic is 362 miles. The road distance is 420.1 miles.
The best way to get from Champaign to Mayo Clinic without a car is to bus via Milwaukee which takes 11h 46m and costs $120 - $190.
It takes approximately 5h 9m to get from Champaign to Mayo Clinic, including transfers.
Champaign to Mayo Clinic bus services, operated by Flixbus USA, depart from Champaign Intermodal Trans Ctr station.
The best way to get from Champaign to Mayo Clinic is to fly which takes 5h 9m and costs $70 - $410. Alternatively, you can bus via Milwaukee, which costs $120 - $190 and takes 11h 46m.
Champaign to Mayo Clinic bus services, operated by Flixbus USA, arrive at Chicago Bus Station.
Yes, the driving distance between Champaign to Mayo Clinic is 420 miles. It takes approximately 7h 57m to drive from Champaign to Mayo Clinic.
What companies run services between Champaign, IL, USA and Mayo Clinic, MN, USA?
American Airlines flies from University Of Illinois Willard Airport (CMI) to Rochester (RST) 3 times a day. Alternatively, you can take a bus from Champaign Intermodal Trans Ctr to Mayo Clinic via Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 11h 46m.
- Website
- aa.com
Flights from University Of Illinois Willard Airport to Rochester via Chicago O'Hare
- Ave. Duration
- 4h 54m
- When
- Every day
- Estimated price
- $55–340
Flights from Central Illinois Regional Airport At Bloomington-Normal to Rochester via Chicago O'Hare
- Ave. Duration
- 8h 14m
- When
- Every day
- Estimated price
- $50–340
- Website
- delta.com
Flights from Central Illinois Regional Airport At Bloomington-Normal to Rochester via Atlanta, Minneapolis
- Ave. Duration
- 10h 3m
- When
- Every day
- Estimated price
- $120–550
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Champaign-Urbana to Chicago Union Station
- Ave. Duration
- 2h 36m
- Frequency
- 3 times a day
- Estimated price
- $70–110
- Website
- Amtrak
Train from Chicago Union Station to St. Paul-Minneapolis
- Ave. Duration
- 7h 31m
- Frequency
- 3 times a day
- Estimated price
- $220–350
- Website
- Amtrak
Train from Champaign-Urbana to Chicago Union Station
- Ave. Duration
- 2h 36m
- Frequency
- 3 times a day
- Estimated price
- $70–110
- Website
- Amtrak
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Champaign Intermodal Trans Ctr to Chicago Bus Station
- Ave. Duration
- 2h 25m
- Frequency
- 4 times a day
- Estimated price
- $21–35
- Schedules at
- Flixbus USA
Bus from Chicago Bus Station to Milwaukee Intermodal Station
- Ave. Duration
- 1h 55m
- Frequency
- 5 times a day
- Estimated price
- $14–21
- Schedules at
- Flixbus USA
Bus from Champaign Intermodal Trans Ctr to Chicago
- Ave. Duration
- 2h 20m
- Frequency
- Once daily
- Estimated price
- $20–30
- Schedules at
- Flixbus USA
Bus from Chicago Bus Station to Madison
- Ave. Duration
- 3h 45m
- Frequency
- 3 times a day
- Estimated price
- $27–45
- Schedules at
- Flixbus USA
- Phone
- +1 800-448-0572
- [email protected]
- Website
- Peoria Charter
Bus from Champaign Intermodal Trans Ctr to Chicago Bus Station
- Ave. Duration
- 3h 10m
- Frequency
- Twice daily
- Estimated price
- $45–60
- Website
- Peoria Charter
- Schedules at
- Peoria Charter Schedules
- cash
- $60
- online
- $45
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Chicago Bus Station to Milwaukee Intermodal Station
- Ave. Duration
- 1h 40m
- Frequency
- Every 4 hours
- Estimated price
- $16–25
- Website
- Greyhound
Bus from Champaign Intermodal Trans Ctr to Bloomington-Normal
- Ave. Duration
- 55 min
- Frequency
- 4 times a day
- Estimated price
- $9–14
- Website
- Greyhound
Bus from Chicago Bus Station to Madison
- Ave. Duration
- 3h 40m
- Frequency
- Twice daily
- Estimated price
- $30–50
- Website
- Greyhound
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Milwaukee to Rochester
- Ave. Duration
- 5h 40m
- Frequency
- Once daily
- Estimated price
- $70–100
- Book at
- Jefferson Lines
- Adult
- $70–100
Bus from St. Paul to Rochester
- Ave. Duration
- 1h 25m
- Frequency
- Once daily
- Estimated price
- $28–40
- Book at
- Jefferson Lines
- Adult
- $28–40
Bus from Madison to Rochester
- Ave. Duration
- 4h 20m
- Frequency
- Once daily
- Estimated price
- $50–75
- Book at
- Jefferson Lines
- Adult
- $50–75
Bus from Madison to Rochester
- Ave. Duration
- 4h 20m
- Frequency
- Once daily
- Estimated price
- $50–75
- Book at
- Jefferson Lines
- Adult
- $50–75
- Phone
- +1 (866) 912 - 6224
- [email protected]
- Website
- Rockland Coaches
Bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campus
- Ave. Duration
- 3h 40m
- Frequency
- Hourly
- Estimated price
- $25–55
- Schedules at
- Rockland Coaches
- Adult
- $25–55
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Booking & Getting There
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