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How to get fromCharleston Amtrak Station to Chicagoby plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, bus, or taxi

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There are 10 ways to get from Charleston Amtrak Station to Chicago by plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, bus, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Charleston International Airport to Chicago Midway International Airport

    best
    1. Fly from Charleston International Airport (CHS) to Chicago Midway International Airport (MDW)plane plane CHS - MDW
    4h 46m
    $79–387

  2. Fly Charleston International Airport to Chicago O'Hare International Airport

    cheapest
    1. Fly from Charleston International Airport (CHS) to Chicago O'Hare International Airport (ORD)plane plane CHS - ORD
    5h 15m
    $69–337

  3. Bus

    1. Take the bus from Charleston Bus Station to Atlanta Bus Stationbus bus Greyhound US0641S
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus Greyhound US0100
    28h 35m
    $181–343

  4. Train via Petersburg (Amtrak)

    1. Take the train from Charleston Amtrak Station to Petersburg Amtrak Stationtrain train Silver Meteor / ...
    2. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train Floridian
    28h 57m
    $408–840

  5. Drive 865 mi

    1. Drive from Charleston Amtrak Station to Chicagocar car 865 mi
    15h 48m
    $158–228

  6. Train to Savannah, fly to Chicago Midway International Airport

    1. Take the train from Charleston Amtrak Station to Savannah Stationtrain train
    2. Fly from Savannah (SAV) to Chicago Midway International Airport (MDW)plane plane SAV - MDW
    5h 56m
    $175–672

  7. Bus to Myrtle Beach, fly to Chicago Midway International Airport

    1. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    2. Fly from Myrtle Beach (MYR) to Chicago Midway International Airport (MDW)plane plane MYR - MDW
    6h 8m
    $93–397

  8. Bus to Myrtle Beach, fly to Chicago O'Hare International Airport

    1. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    2. Fly from Myrtle Beach (MYR) to Chicago O'Hare International Airport (ORD)plane plane MYR - ORD
    6h 38m
    $83–347

  9. Train, taxi to Hilton Head Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Charleston Amtrak Station to Savannah Stationtrain train
    2. Take the taxi from Savannah Station to Hilton Head Airport (HHH)taxi taxi
    3. Fly from Hilton Head Airport (HHH) to Chicago O'Hare International Airport (ORD)plane plane HHH - ORD
    7h 5m
    $250–592

  10. Train (Amtrak)

    1. Take the train from Charleston Amtrak Station to Savannah Stationtrain train Silver Meteor / ...
    2. Take the train from Savannah Station to Chicago Union Stationtrain train Floridian
    34h 51m
    $483–1,017

Charleston Amtrak Station to Chicago by bus

Calendar7Weekly Buses
Duration28h 35mAverage Duration
Ticket$181Cheapest Price
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Questions & Answers

Map of how to get from Charleston Amtrak Station to Chicago.ExpandLaunch map view
  • Distance: 762.5 mi
  • Duration: 4h 46m

What companies run services between Charleston Amtrak Station, SC, USA and Chicago, IL, USA?

Southwest Airlines and Delta fly from Charleston International Airport (CHS) to Chicago Midway International Airport (MDW) every 4 hours. Alternatively, you can take a bus from Charleston Bus Station to Chicago Bus Station via Atlanta Bus Station in around 28h 35m.

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