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How to get fromCharleston Amtrak Station to Knoxvilleby plane, bus, shuttle, car, or taxi

Find Transport to Knoxville

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There are 5 ways to get from Charleston Amtrak Station to Knoxville by plane, bus, shuttle, car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Charleston International Airport (CHS) to Mcghee Tyson Airport (TYS)plane plane CHS - TYS
    5h 26m
    $157–722

  2. Drive 364.2 mi

    cheapest
    1. Drive from Charleston Amtrak Station to Knoxvillecar car 364.2 mi
    6h 12m
    $67–96

  3. Bus, shuttle, drive

    1. Take the bus from Charleston Bus Station to Charlotte Bus Stationbus bus
    2. Take the bus from Charlotte Airport to ASU Peacock Hall Boonebus bus
    3. Take a shuttle bus from Boone to Black Bear Resortshuttle bus
    4. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    5. Drive from Hot Springs to Knoxvillecar car
    16h 17m
    $372–439

  4. Fly to Nashville, drive

    1. Fly from Charleston International Airport (CHS) to Nashville (BNA)plane plane CHS - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    6h 13m
    $382–1,152

  5. Bus, taxi, shuttle, drive

    1. Take the bus from Charleston Bus Station to Charlotte Bus Stationbus bus
    2. Take the bus from Charlotte Airport to ASU Peacock Hall Boonebus bus
    3. Take the taxi from ASU Peacock Hall Boone to Black Bear Resorttaxi taxi
    4. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    5. Drive from Hot Springs to Chilhowee at Holstoncar car
    16h 32m
    $407–504

Charleston International Airport (CHS) to Mcghee Tyson Airport (TYS) flights

Calendar104Weekly Planes
Duration4h 20mAverage Duration
Ticket$100Cheapest Price
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Questions & Answers

Map of how to get from Charleston Amtrak Station to Knoxville.ExpandLaunch map view
  • Distance: 321 mi
  • Duration: 5h 26m

What companies run services between Charleston Amtrak Station, SC, USA and Knoxville, TN, USA?

Delta, American Airlines, and two other airlines fly from Charleston International Airport (CHS) to Mcghee Tyson Airport (TYS) hourly.

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