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How to get fromCharleston Amtrak Station to Louisvilleby plane, bus (Greyhound, Flixbus, Amtrak), car, train, or bus (Greyhound, Flixbus)

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There are 6 ways to get from Charleston Amtrak Station to Louisville by plane, bus (Greyhound, Flixbus, Amtrak), car, train, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Charleston International Airport to Louisville International Airport

    best
    1. Fly from Charleston International Airport (CHS) to Louisville International Airport (SDF)plane plane CHS - SDF
    4h 57m
    $343–405

  2. Drive 572.7 mi

    cheapest
    1. Drive from Charleston Amtrak Station to Louisvillecar car 572.7 mi
    11h 7m
    $105–151

  3. Bus

    1. Take the bus from Charleston Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville to Louisville, KYbus bus
    21h 8m
    $135–251

  4. Fly Charleston International Airport to Blue Grass Airport, drive

    1. Fly from Charleston International Airport (CHS) to Blue Grass Airport (LEX)plane plane CHS - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    6h 43m
    $135–721

  5. Train to Savannah, fly to Louisville International Airport

    1. Take the train from Charleston Amtrak Station to Savannah Stationtrain train
    2. Fly from Savannah (SAV) to Louisville International Airport (SDF)plane plane SAV - SDF
    7h 52m
    $193–820

  6. Bus via Preston @ Vim

    1. Take the bus from Charleston Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Tornado Bus Co - Nashville to La Tropicana - Louisville, KYbus bus
    22h
    $158–356

Charleston Amtrak Station to Louisville by bus

Calendar14Weekly Buses
Duration21h 8mAverage Duration
Ticket$135Cheapest Price
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Questions & Answers

Map of how to get from Charleston Amtrak Station to Louisville.ExpandLaunch map view
  • Distance: 498.3 mi
  • Duration: 4h 57m

What companies run services between Charleston Amtrak Station, SC, USA and Louisville, KY, USA?

Breeze Airways, American Airlines, and three other airlines fly from Charleston International Airport (CHS) to Louisville International Airport (SDF) every 4 hours. Alternatively, you can take a bus from Charleston Bus Station to Louisville, KY via Atlanta Bus Station and Nashville in around 21h 8m.

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Bus operators

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