Rome2Rio

How to get fromCharleston Amtrak Station to St. Louisby plane, bus (Greyhound, Flixbus, Amtrak), train (Amtrak), car, train, bus, or bus (Greyhound, Flixbus)

Find Transport to St. Louis

See all options

There are 7 ways to get from Charleston Amtrak Station to St. Louis by plane, bus (Greyhound, Flixbus, Amtrak), train (Amtrak), car, train, bus, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Charleston International Airport

    best
    1. Fly from Charleston International Airport (CHS) to Lambert–St. Louis International Airport (STL)plane plane CHS - STL
    4h 42m
    $105–555

  2. Bus via Carbondale

    1. Take the bus from Charleston Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Carbondale Intermodal Stationbus bus
    3. Take the bus from Carbondale Intermodal Station to St Louis Bus Stationbus bus
    23h 51m
    $155–297

  3. Train (Amtrak)

    1. Take the train from Charleston Amtrak Station to Petersburg Amtrak Stationtrain train
    2. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    34h 43m
    $497–1,029

  4. Drive 832.5 mi

    1. Drive from Charleston Amtrak Station to St. Louiscar car 832.5 mi
    14h 33m
    $152–220

  5. Train to Savannah, fly

    1. Take the train from Charleston Amtrak Station to Savannah Stationtrain train
    2. Fly from Savannah (SAV) to Lambert–St. Louis International Airport (STL)plane plane SAV - STL
    5h 47m
    $215–870

  6. Bus to Myrtle Beach, fly

    1. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    2. Fly from Myrtle Beach (MYR) to Lambert–St. Louis International Airport (STL)plane plane MYR - STL
    6h 9m
    $124–545

  7. Bus

    1. Take the bus from Charleston Bus Station to Atlanta Bus Stationbus bus Greyhound US0641S
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus Greyhound US0186
    24h 15m
    $150–292

Charleston Amtrak Station to St. Louis by bus

Calendar10Weekly Buses
Duration23h 51mAverage Duration
Ticket$155Cheapest Price
See schedules

Questions & Answers

Map of how to get from Charleston Amtrak Station to St. Louis.ExpandLaunch map view
  • Distance: 724.9 mi
  • Duration: 4h 42m

What companies run services between Charleston Amtrak Station, SC, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and American Airlines fly from Charleston International Airport (CHS) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from Charleston Bus Station to St Louis Bus Station via Atlanta Bus Station and Carbondale Intermodal Station in around 23h 51m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers