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How to get fromCharleston to Des Moinesby plane, train, bus, or car

Find Transport to Des Moines

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There are 5 ways to get from Charleston to Des Moines by plane, train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Charleston International Airport

    best
    1. Fly from Charleston International Airport (CHS) to Des Moines (DSM)plane plane CHS - DSM
    5h 55m
    $175–757

  2. Train, bus

    1. Take the train from Charleston Amtrak Station to Petersburg Amtrak Stationtrain train
    2. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    4. Take the bus from Galesburg to Des Moinesbus bus
    38h 41m
    $511–1,056

  3. Train, bus via Newark

    1. Take the train from Charleston Amtrak Station to Newark Penn Stationtrain train
    2. Take the bus from Newark Penn Station to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    44h 36m
    $414–844

  4. Drive 1,160.5 mi

    1. Drive from Charleston to Des Moinescar car 1,160.5 mi
    20h 43m
    $212–306

  5. Drive to Hilton Head Airport, fly

    1. Drive from Charleston to Hilton Head Airport (HHH)car car
    2. Fly from Hilton Head Airport (HHH) to Des Moines (DSM)plane plane HHH - DSM
    7h 19m
    $196–798

Charleston to Des Moines by bus and train

Calendar7Weekly Services
Duration44h 36mAverage Duration
Ticket$414Cheapest Price
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Questions & Answers

Map of how to get from Charleston to Des Moines.ExpandLaunch map view
  • Distance: 974.4 mi
  • Duration: 5h 55m

What companies run services between Charleston, SC, USA and Des Moines, IA, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Charleston International Airport (CHS) to Des Moines (DSM) hourly.

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