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How to get fromCharleston to Durhamby train (Amtrak), bus (Greyhound), car, plane, or train

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There are 7 ways to get from Charleston to Durham by train (Amtrak), bus (Greyhound), car, plane, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Charleston Amtrak Station to Selma Stationtrain train Palmetto
    2. Take the train from Selma Station to Durham Amtrak Stationtrain train Carolinian
    6h 35m
    $181–286

  2. Drive  258.9 mi

    cheapest
    1. Drive from Charleston to Durhamcar car 258.9 mi
    5h 43m
    $48–69

  3. Bus (Greyhound)

    1. Take the bus from Charleston Bus Station to Raleigh Bus Stationbus bus Greyhound US0645S
    10h 23m
    $57–90

  4. Fly Charleston International Airport to Raleigh-Durham International Airport

    1. Fly from Charleston International Airport (CHS) to Raleigh-Durham International Airport (RDU)plane plane CHS - RDU
    6h 18m
    $276–511

  5. Fly Charleston International Airport to Piedmont Triad International Airport, train

    1. Fly from Charleston International Airport (CHS) to Piedmont Triad International Airport (GSO)plane plane CHS - GSO
    2. Take the train from Greensboro to Durham Amtrak Stationtrain train
    6h 43m
    $170–828

  6. Drive to Hilton Head Airport, fly to Raleigh-Durham International Airport

    1. Drive from Charleston to Hilton Head Airport (HHH)car car
    2. Fly from Hilton Head Airport (HHH) to Raleigh-Durham International Airport (RDU)plane plane HHH - RDU
    6h 55m
    $85–443

  7. Fly Charleston International Airport to Charlotte Douglas International Airport, train

    1. Fly from Charleston International Airport (CHS) to Charlotte Douglas International Airport (CLT)plane plane CHS - CLT
    2. Take the train from Charlotte Amtrak Station to Durham Amtrak Stationtrain train
    7h 12m
    $154–631

Charleston to Durham by bus (Greyhound)

Calendar7Weekly Buses
Duration10h 23mAverage Duration
Ticket$57Cheapest Price
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Comparing Your Travel Options

Map of how to get from Charleston to Durham.ExpandLaunch map view
  • Distance: 288.9 mi
  • Duration: 6h 35m

What companies run services between Charleston, SC, USA and Durham, NC, USA?

You can take a vehicle from Charleston to Durham Amtrak Station via Charleston Amtrak Station and Selma Station in around 6h 35m. Alternatively, Greyhound USA operates a bus from Charleston Bus Station to Raleigh Bus Station once daily. Tickets cost $50–80 and the journey takes 6h 20m.

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Train operators
Bus operators

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