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How to get fromCharleston to Durhamby train (Amtrak), bus (Greyhound), car, plane, or train

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There are 7 ways to get from Charleston to Durham by train (Amtrak), bus (Greyhound), car, plane, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Charleston Amtrak Station to Selma Stationtrain train Palmetto
    2. Take the train from Selma Station to Durham Amtrak Stationtrain train Carolinian
    6h 35m
    $118–226

  2. Drive 258.9 mi

    cheapest
    1. Drive from Charleston to Durhamcar car 258.9 mi
    5h 43m
    $48–69

  3. Bus (Greyhound)

    1. Take the bus from Charleston Bus Station to Raleigh Bus Stationbus bus Greyhound US0645S
    11h 43m
    $62–121

  4. Fly Charleston International Airport to Raleigh-Durham International Airport

    1. Fly from Charleston International Airport (CHS) to Raleigh-Durham International Airport (RDU)plane plane CHS - RDU
    5h 57m
    $256–596

  5. Fly Charleston International Airport to Piedmont Triad International Airport, train

    1. Fly from Charleston International Airport (CHS) to Piedmont Triad International Airport (GSO)plane plane CHS - GSO
    2. Take the train from Greensboro to Durham Amtrak Stationtrain train
    6h 43m
    $365–1,349

  6. Drive to Hilton Head Airport, fly to Raleigh-Durham International Airport

    1. Drive from Charleston to Hilton Head Airport (HHH)car car
    2. Fly from Hilton Head Airport (HHH) to Raleigh-Durham International Airport (RDU)plane plane HHH - RDU
    7h 17m
    $80–383

  7. Fly Charleston International Airport to Charlotte Douglas International Airport, train

    1. Fly from Charleston International Airport (CHS) to Charlotte Douglas International Airport (CLT)plane plane CHS - CLT
    2. Take the train from Charlotte Amtrak Station to Durham Amtrak Stationtrain train
    7h 14m
    $109–518

Charleston to Durham by bus (Greyhound)

Calendar7Weekly Buses
Duration11h 43mAverage Duration
Ticket$62Cheapest Price
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Questions & Answers

Map of how to get from Charleston to Durham.ExpandLaunch map view
  • Distance: 288.9 mi
  • Duration: 6h 35m

What companies run services between Charleston, SC, USA and Durham, NC, USA?

You can take a vehicle from Charleston to Durham Amtrak Station via Charleston Amtrak Station and Selma Station in around 6h 35m. Alternatively, Greyhound USA operates a bus from Charleston Bus Station to Raleigh Bus Station once daily. Tickets cost $55–110 and the journey takes 7h 45m.

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Train operators
Bus operators

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