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How to get fromCharleston to Florida Keysby plane, train, bus, car, or shuttle

Find Transport to Florida Keys

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There are 6 ways to get from Charleston to Florida Keys by plane, train, bus, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Key West International Airport

    best
    1. Fly from Charleston International Airport (CHS) to Key West International Airport (EYW)plane plane CHS - EYW
    7h 59m
    $137–429

  2. Drive  726.2 mi

    cheapest
    1. Drive from Charleston to Florida Keyscar car 726.2 mi
    12h 52m
    $133–192

  3. Train, bus

    1. Take the train from Charleston Amtrak Station to Hollywood Amtrak Stationtrain train Silver Meteor
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus Greyhound US0720s
    20h 56m
    $408–631

  4. Fly to Miami International Airport, shuttle

    1. Fly from Charleston International Airport (CHS) to Miami International Airport (MIA)plane plane CHS - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    8h 33m
    $638–1,138

  5. Fly to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Charleston International Airport (CHS) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane CHS - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 2m
    $576–771

  6. Train, bus, shuttle

    1. Take the train from Charleston Amtrak Station to West Palm Beach Amtrak Stationtrain train
    2. Take the bus from West Palm Beach, FL to Fort Lauderdale Airportbus bus
    3. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Summerland Key - Mote Marine Labshuttle bus
    22h 45m
    $507–774

Charleston to Florida Keys by bus, train, shuttle, and foot

Calendar7Weekly Services
Duration22h 45mAverage Duration
Ticket$507Cheapest Price
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Comparing Your Travel Options

Map of how to get from Charleston to Florida Keys.ExpandLaunch map view
  • Distance: 617.8 mi
  • Duration: 7h 59m

What companies run services between Charleston, SC, USA and Florida Keys, FL, USA?

American Airlines, Delta, and Breeze Airways fly from Charleston International Airport (CHS) to Key West International Airport (EYW) every 3 hours.

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